Rickets Types and Treatment with Vitamin D and Analogues
The definition of “Vitamin D” encompasses a group of fat-soluble steroid compounds of different origins with similar chemical structures and the same biological effects. Vitamin D deficiency and/or a defect in the process of its synthesis or transport predispose individuals to several types of ricke...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/416 |
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| author | Giacomo Biasucci Valentina Donini Giuseppe Cannalire |
| author_facet | Giacomo Biasucci Valentina Donini Giuseppe Cannalire |
| author_sort | Giacomo Biasucci |
| collection | DOAJ |
| description | The definition of “Vitamin D” encompasses a group of fat-soluble steroid compounds of different origins with similar chemical structures and the same biological effects. Vitamin D deficiency and/or a defect in the process of its synthesis or transport predispose individuals to several types of rickets. In addition to cholecalciferol, ergocalciferol, and vitamins D3 and D2, there are also active metabolites for the treatment of this condition which are commercially available. Calcitriol and aphacalcidiol are active metabolites that do not require the renal activation step, which is required with calcifediol, or hepatic activation. The purpose of this review is to summarize current approaches to the treatment of rickets for generalist physicians, focusing on the best vitamin D form to be used in each type, or, in the case of X-linked hypophosphatemic rickets (XLH), on both conventional and innovative monoclonal antibody treatments. |
| first_indexed | 2024-03-08T03:50:38Z |
| format | Article |
| id | doaj.art-55abdb98e71b4abeb42f5f580f73beee |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:50:38Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-55abdb98e71b4abeb42f5f580f73beee2024-02-09T15:19:54ZengMDPI AGNutrients2072-66432024-01-0116341610.3390/nu16030416Rickets Types and Treatment with Vitamin D and AnaloguesGiacomo Biasucci0Valentina Donini1Giuseppe Cannalire2Pediatrics and Neonatology Unit, University of Parma, Gugliemo da Saliceto Hospital, 29121 Piacenza, ItalyUnit of Pediatrics, Department of Medicine and Surgery, University of Parma, 43121 Parma, ItalyPediatrics and Neonatology Unit, University of Parma, Gugliemo da Saliceto Hospital, 29121 Piacenza, ItalyThe definition of “Vitamin D” encompasses a group of fat-soluble steroid compounds of different origins with similar chemical structures and the same biological effects. Vitamin D deficiency and/or a defect in the process of its synthesis or transport predispose individuals to several types of rickets. In addition to cholecalciferol, ergocalciferol, and vitamins D3 and D2, there are also active metabolites for the treatment of this condition which are commercially available. Calcitriol and aphacalcidiol are active metabolites that do not require the renal activation step, which is required with calcifediol, or hepatic activation. The purpose of this review is to summarize current approaches to the treatment of rickets for generalist physicians, focusing on the best vitamin D form to be used in each type, or, in the case of X-linked hypophosphatemic rickets (XLH), on both conventional and innovative monoclonal antibody treatments.https://www.mdpi.com/2072-6643/16/3/416ricketsergocalciferolcholecalciferolFGF23Burosumab |
| spellingShingle | Giacomo Biasucci Valentina Donini Giuseppe Cannalire Rickets Types and Treatment with Vitamin D and Analogues Nutrients rickets ergocalciferol cholecalciferol FGF23 Burosumab |
| title | Rickets Types and Treatment with Vitamin D and Analogues |
| title_full | Rickets Types and Treatment with Vitamin D and Analogues |
| title_fullStr | Rickets Types and Treatment with Vitamin D and Analogues |
| title_full_unstemmed | Rickets Types and Treatment with Vitamin D and Analogues |
| title_short | Rickets Types and Treatment with Vitamin D and Analogues |
| title_sort | rickets types and treatment with vitamin d and analogues |
| topic | rickets ergocalciferol cholecalciferol FGF23 Burosumab |
| url | https://www.mdpi.com/2072-6643/16/3/416 |
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