Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death

Sirtuin-1 (SIRT1) is a critical nuclear deacetylase that participates in a wide range of biological processes. We hereby employed quantitative acetyl-proteomics to globally reveal the landscape of SIRT1-dependent acetylation in colorectal cancer (CRC) cells stimulated by specific SIRT1 inhibitor Ina...

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Bibliographic Details
Main Authors: Yue Sun, Yan-Ming Yang, Yu-Yu Hu, Lan Ouyang, Zheng-Hua Sun, Xing-Feng Yin, Nan Li, Qing-Yu He, Yang Wang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Redox Biology
Subjects:
SIRT1
Inauhzin
MCU
Mitochondria
Acetylation
Calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001069

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