Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis
In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to the therapeutic use of probiotics for stress-related disorders. In this study, we explored the potential antidepressant efficacy of a multi-strain probiotics treatment (Lactobacill...
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00266/full |
| _version_ | 1811231081482944512 |
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| author | Nannan Li Qi Wang Yan Wang Anji Sun Yiwei Lin Ye Jin Xiaobai Li |
| author_facet | Nannan Li Qi Wang Yan Wang Anji Sun Yiwei Lin Ye Jin Xiaobai Li |
| author_sort | Nannan Li |
| collection | DOAJ |
| description | In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to the therapeutic use of probiotics for stress-related disorders. In this study, we explored the potential antidepressant efficacy of a multi-strain probiotics treatment (Lactobacillus helveticus R0052, Lactobacillus plantarum R1012, and Bifidobacterium longum R0175) in a chronic mild stress (CMS) mouse model of depression and determined its probable mechanism of action. Our findings revealed that mice subjected to CMS exhibited anxiety- and depressive-like behaviors in the sucrose preference test, elevated plus maze, and forced swim test, along with increased interferon-γ, tumor necrosis factor-α, and indoleamine 2,3-dioxygenase-1 levels in the hippocampus. Moreover, the microbiota distinctly changed from the non-stress group and was characterized by highly diverse bacterial communities associated with significant reductions in Lactobacillus species. Probiotics attenuated CMS-induced anxiety- and depressive-like behaviors, significantly increased Lactobacillus abundance, and reversed the CMS-induced immune changes in the hippocampus. Thus, the possible mechanism involved in the antidepressant-like activity of probiotics is correlated with Lactobacillus species via the gut microbiota-inflammation-brain axis. |
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| format | Article |
| id | doaj.art-55ade276b0a04d73ae7a331449d74afa |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T10:39:12Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-55ade276b0a04d73ae7a331449d74afa2022-12-22T03:36:38ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532018-11-011210.3389/fnbeh.2018.00266418686Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation AxisNannan Li0Qi Wang1Yan Wang2Anji Sun3Yiwei Lin4Ye Jin5Xiaobai Li6Department of Geriatrics Cardiology, First Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Mental Health Center, China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Hospital of China Medical University, Shenyang, ChinaIn recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to the therapeutic use of probiotics for stress-related disorders. In this study, we explored the potential antidepressant efficacy of a multi-strain probiotics treatment (Lactobacillus helveticus R0052, Lactobacillus plantarum R1012, and Bifidobacterium longum R0175) in a chronic mild stress (CMS) mouse model of depression and determined its probable mechanism of action. Our findings revealed that mice subjected to CMS exhibited anxiety- and depressive-like behaviors in the sucrose preference test, elevated plus maze, and forced swim test, along with increased interferon-γ, tumor necrosis factor-α, and indoleamine 2,3-dioxygenase-1 levels in the hippocampus. Moreover, the microbiota distinctly changed from the non-stress group and was characterized by highly diverse bacterial communities associated with significant reductions in Lactobacillus species. Probiotics attenuated CMS-induced anxiety- and depressive-like behaviors, significantly increased Lactobacillus abundance, and reversed the CMS-induced immune changes in the hippocampus. Thus, the possible mechanism involved in the antidepressant-like activity of probiotics is correlated with Lactobacillus species via the gut microbiota-inflammation-brain axis.https://www.frontiersin.org/article/10.3389/fnbeh.2018.00266/fullprobioticsLactobacillusBifidobacteriachronic mild stressmicrobiotainflammation |
| spellingShingle | Nannan Li Qi Wang Yan Wang Anji Sun Yiwei Lin Ye Jin Xiaobai Li Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis Frontiers in Behavioral Neuroscience probiotics Lactobacillus Bifidobacteria chronic mild stress microbiota inflammation |
| title | Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis |
| title_full | Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis |
| title_fullStr | Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis |
| title_full_unstemmed | Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis |
| title_short | Oral Probiotics Ameliorate the Behavioral Deficits Induced by Chronic Mild Stress in Mice via the Gut Microbiota-Inflammation Axis |
| title_sort | oral probiotics ameliorate the behavioral deficits induced by chronic mild stress in mice via the gut microbiota inflammation axis |
| topic | probiotics Lactobacillus Bifidobacteria chronic mild stress microbiota inflammation |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00266/full |
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