Regulation of biofilm formation by non-coding RNA in prokaryotes
Biofilm refers to microbes that associate with each other or to a surface via self-synthesized exopolysaccharides and other surface-related structures. The presence of biofilms consisting of pathogenic microbes in the food and clinical environment can pose a threat to human health as microbes in bio...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257122000712 |
| _version_ | 1797796319927992320 |
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| author | Arindam Mitra Suman Mukhopadhyay |
| author_facet | Arindam Mitra Suman Mukhopadhyay |
| author_sort | Arindam Mitra |
| collection | DOAJ |
| description | Biofilm refers to microbes that associate with each other or to a surface via self-synthesized exopolysaccharides and other surface-related structures. The presence of biofilms consisting of pathogenic microbes in the food and clinical environment can pose a threat to human health as microbes in biofilms are highly robust and are difficult to remove. Understanding the process of biofilm formation is crucial for the development of novel strategies to control or harness biofilm. The complex network of proteins, small RNA, and diverse molecules regulate biofilm formation at different steps in biofilm development, including triggering the switch from planktonic to sessile cells, maturation of biofilms, and eventual dispersion of microbes from the biofilms. Small non-coding RNAs are relatively small RNAs that are not translated into proteins and play diverse roles in metabolism, physiology, pathogenesis, and biofilm formation. In this review, we primarily focused on non-coding regulatory RNA that regulates biofilm formation in clinically relevant pathogens or threatens human health. Even though many ncRNA have recently been identified in Archaea, much characterization work remains. The mechanisms and regulatory processes controlled by ncRNA in prokaryotes are covered in this review. |
| first_indexed | 2024-03-13T03:31:17Z |
| format | Article |
| id | doaj.art-55b0231624c2455c903f58e854b5a896 |
| institution | Directory Open Access Journal |
| issn | 2590-2571 |
| language | English |
| last_indexed | 2024-03-13T03:31:17Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj.art-55b0231624c2455c903f58e854b5a8962023-06-24T05:19:01ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712023-01-014100151Regulation of biofilm formation by non-coding RNA in prokaryotesArindam Mitra0Suman Mukhopadhyay1Department of Biological Sciences, School of Life Science and Biotechnology, Adamas University, Kolkata, India; Corresponding author.Division of Microbiology and Infectious Diseases HHS/NIH/National Institute of Allergy and Infectious Disease, Rockville, MD, 20852, USA; Corresponding author.Biofilm refers to microbes that associate with each other or to a surface via self-synthesized exopolysaccharides and other surface-related structures. The presence of biofilms consisting of pathogenic microbes in the food and clinical environment can pose a threat to human health as microbes in biofilms are highly robust and are difficult to remove. Understanding the process of biofilm formation is crucial for the development of novel strategies to control or harness biofilm. The complex network of proteins, small RNA, and diverse molecules regulate biofilm formation at different steps in biofilm development, including triggering the switch from planktonic to sessile cells, maturation of biofilms, and eventual dispersion of microbes from the biofilms. Small non-coding RNAs are relatively small RNAs that are not translated into proteins and play diverse roles in metabolism, physiology, pathogenesis, and biofilm formation. In this review, we primarily focused on non-coding regulatory RNA that regulates biofilm formation in clinically relevant pathogens or threatens human health. Even though many ncRNA have recently been identified in Archaea, much characterization work remains. The mechanisms and regulatory processes controlled by ncRNA in prokaryotes are covered in this review.http://www.sciencedirect.com/science/article/pii/S2590257122000712Non-coding RNABiofilmRegulationVirulence |
| spellingShingle | Arindam Mitra Suman Mukhopadhyay Regulation of biofilm formation by non-coding RNA in prokaryotes Current Research in Pharmacology and Drug Discovery Non-coding RNA Biofilm Regulation Virulence |
| title | Regulation of biofilm formation by non-coding RNA in prokaryotes |
| title_full | Regulation of biofilm formation by non-coding RNA in prokaryotes |
| title_fullStr | Regulation of biofilm formation by non-coding RNA in prokaryotes |
| title_full_unstemmed | Regulation of biofilm formation by non-coding RNA in prokaryotes |
| title_short | Regulation of biofilm formation by non-coding RNA in prokaryotes |
| title_sort | regulation of biofilm formation by non coding rna in prokaryotes |
| topic | Non-coding RNA Biofilm Regulation Virulence |
| url | http://www.sciencedirect.com/science/article/pii/S2590257122000712 |
| work_keys_str_mv | AT arindammitra regulationofbiofilmformationbynoncodingrnainprokaryotes AT sumanmukhopadhyay regulationofbiofilmformationbynoncodingrnainprokaryotes |