Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study
Abstract Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. However, little is known about how affective arousal in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-022-00234-y |
| _version_ | 1797642640945053696 |
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| author | Hong-Hsiang Liu Chih-Min Liu Ming H. Hsieh Yi-Ling Chien Yung-Fong Hsu Wen-Sung Lai |
| author_facet | Hong-Hsiang Liu Chih-Min Liu Ming H. Hsieh Yi-Ling Chien Yung-Fong Hsu Wen-Sung Lai |
| author_sort | Hong-Hsiang Liu |
| collection | DOAJ |
| description | Abstract Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. However, little is known about how affective arousal influences reward-based decision-making in SZ. Taking advantage of a two-choice probabilistic gambling task and utilizing three facial expressions as affective primes (i.e., neutral, angry, and happy conditions) in each trial, we investigated how affective arousal influences reward-related choice based on behavioral, model fitting, and feedback-related negativity (FRN) data in 38 SZ and 26 healthy controls (CTRL). We also correlated our measurements with patients’ symptom severity. Compared with the CTRL group, SZ expressed blunted responses to angry facial primes. They had lower total game scores and displayed more maladaptive choice strategies (i.e., less win-stay and more lose-shift) and errors in monitoring rewards. Model fitting results revealed that the SZ group had a higher learning rate and lower choice consistency, especially in the happy condition. Brain activity data further indicated that SZ had smaller amplitudes of FRN than their controls in the angry and happy conditions. Importantly, the SZ group exhibited attenuated affective influence on decision-making, and their impairments in decision-making were only correlated with their clinical symptoms in the angry condition. Our findings imply the affective processing is dysregulated in SZ and it is selectively involved in the regulation of choice strategies, choice behaviors, and FRN in SZ, which lead to impairments in reward-related decision-making, especially in the angry condition. |
| first_indexed | 2024-03-11T14:04:12Z |
| format | Article |
| id | doaj.art-55b093468d8649bd880e6476077992d1 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-11T14:04:12Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-55b093468d8649bd880e6476077992d12023-11-02T03:18:44ZengNature Portfolionpj Schizophrenia2334-265X2022-03-018111010.1038/s41537-022-00234-yDysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated studyHong-Hsiang Liu0Chih-Min Liu1Ming H. Hsieh2Yi-Ling Chien3Yung-Fong Hsu4Wen-Sung Lai5Department of Psychology, National Taiwan UniversityDepartment of Psychiatry, National Taiwan University HospitalDepartment of Psychiatry, National Taiwan University HospitalDepartment of Psychiatry, National Taiwan University HospitalDepartment of Psychology, National Taiwan UniversityDepartment of Psychology, National Taiwan UniversityAbstract Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. However, little is known about how affective arousal influences reward-based decision-making in SZ. Taking advantage of a two-choice probabilistic gambling task and utilizing three facial expressions as affective primes (i.e., neutral, angry, and happy conditions) in each trial, we investigated how affective arousal influences reward-related choice based on behavioral, model fitting, and feedback-related negativity (FRN) data in 38 SZ and 26 healthy controls (CTRL). We also correlated our measurements with patients’ symptom severity. Compared with the CTRL group, SZ expressed blunted responses to angry facial primes. They had lower total game scores and displayed more maladaptive choice strategies (i.e., less win-stay and more lose-shift) and errors in monitoring rewards. Model fitting results revealed that the SZ group had a higher learning rate and lower choice consistency, especially in the happy condition. Brain activity data further indicated that SZ had smaller amplitudes of FRN than their controls in the angry and happy conditions. Importantly, the SZ group exhibited attenuated affective influence on decision-making, and their impairments in decision-making were only correlated with their clinical symptoms in the angry condition. Our findings imply the affective processing is dysregulated in SZ and it is selectively involved in the regulation of choice strategies, choice behaviors, and FRN in SZ, which lead to impairments in reward-related decision-making, especially in the angry condition.https://doi.org/10.1038/s41537-022-00234-y |
| spellingShingle | Hong-Hsiang Liu Chih-Min Liu Ming H. Hsieh Yi-Ling Chien Yung-Fong Hsu Wen-Sung Lai Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study npj Schizophrenia |
| title | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study |
| title_full | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study |
| title_fullStr | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study |
| title_full_unstemmed | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study |
| title_short | Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study |
| title_sort | dysregulated affective arousal regulates reward based decision making in patients with schizophrenia an integrated study |
| url | https://doi.org/10.1038/s41537-022-00234-y |
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