IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury

IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family and an extracellular ligand for the orphan IL-1 receptor ST2. Accumulated evidence shows that the IL-33/ST2 axis plays a crucial role in the pathogenesis of central nervous system (CNS) diseases and injury, including trau...

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Bibliographic Details
Main Authors: Yuan Gao, Ming-yang Zhang, Tao Wang, Yan-yan Fan, Lin-sheng Yu, Guang-hua Ye, Zu-feng Wang, Cheng Gao, Hao-chen Wang, Cheng-liang Luo, Lu-yang Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autophagy
endoplasmic reticulum (ER) stress
IL-33-ST2L signaling
neurobehavioral deficits
traumatic brain injury
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00095/full

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