PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS
This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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InterMedservice
2015-06-01
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| Series: | Евразийский Кардиологический Журнал |
| Subjects: | |
| Online Access: | https://www.heartj.asia/jour/article/view/5635 |
| _version_ | 1797879229917954048 |
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| author | U. R. Makhmudova Sh. U. Hoshimov G. J. Abdullayeva A. B. Shek R. D. Kurbanov |
| author_facet | U. R. Makhmudova Sh. U. Hoshimov G. J. Abdullayeva A. B. Shek R. D. Kurbanov |
| author_sort | U. R. Makhmudova |
| collection | DOAJ |
| description | This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differentiated approach to their appointment and choice. This will not only increase the effectiveness of statins, but also to avoid serious side effects, primarily statin-induced myopathy and toxic hepatitis. |
| first_indexed | 2024-04-10T02:45:33Z |
| format | Article |
| id | doaj.art-55b448e7bcf34034bcf29714f243f3d8 |
| institution | Directory Open Access Journal |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| last_indexed | 2024-04-10T02:45:33Z |
| publishDate | 2015-06-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj.art-55b448e7bcf34034bcf29714f243f3d82023-03-13T07:47:27ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482015-06-0102576110.38109/2225-1685-2015-2-57-615632PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSISU. R. Makhmudova0Sh. U. Hoshimov1G. J. Abdullayeva2A. B. Shek3R. D. Kurbanov4Ташкентская медицинская академияРеспубликанский специализированный центр кардиологии МЗ РУзРеспубликанский специализированный центр кардиологии МЗ РУзРеспубликанский специализированный центр кардиологии МЗ РУзРеспубликанский специализированный центр кардиологии МЗ РУзThis review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differentiated approach to their appointment and choice. This will not only increase the effectiveness of statins, but also to avoid serious side effects, primarily statin-induced myopathy and toxic hepatitis.https://www.heartj.asia/jour/article/view/5635статиныполиморфизмы генов метаболизма печениперсонализированная фармакотерапияstatinshepatic metabolism genes polymorphismspersonalized pharmacotherapy |
| spellingShingle | U. R. Makhmudova Sh. U. Hoshimov G. J. Abdullayeva A. B. Shek R. D. Kurbanov PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS Евразийский Кардиологический Журнал статины полиморфизмы генов метаболизма печени персонализированная фармакотерапия statins hepatic metabolism genes polymorphisms personalized pharmacotherapy |
| title | PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS |
| title_full | PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS |
| title_fullStr | PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS |
| title_full_unstemmed | PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS |
| title_short | PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS |
| title_sort | personalized statin therapy in improving the treatment of coronary artery disease and atherosclerosis |
| topic | статины полиморфизмы генов метаболизма печени персонализированная фармакотерапия statins hepatic metabolism genes polymorphisms personalized pharmacotherapy |
| url | https://www.heartj.asia/jour/article/view/5635 |
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