The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Tau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates seeding-active Tau species as byproduct.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36058-2 |
| _version_ | 1811171624242642944 |
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| author | Itika Saha Patricia Yuste-Checa Miguel Da Silva Padilha Qiang Guo Roman Körner Hauke Holthusen Victoria A. Trinkaus Irina Dudanova Rubén Fernández-Busnadiego Wolfgang Baumeister David W. Sanders Saurabh Gautam Marc I. Diamond F. Ulrich Hartl Mark S. Hipp |
| author_facet | Itika Saha Patricia Yuste-Checa Miguel Da Silva Padilha Qiang Guo Roman Körner Hauke Holthusen Victoria A. Trinkaus Irina Dudanova Rubén Fernández-Busnadiego Wolfgang Baumeister David W. Sanders Saurabh Gautam Marc I. Diamond F. Ulrich Hartl Mark S. Hipp |
| author_sort | Itika Saha |
| collection | DOAJ |
| description | Tau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates seeding-active Tau species as byproduct. |
| first_indexed | 2024-04-10T17:17:11Z |
| format | Article |
| id | doaj.art-55b4a135031e4d249c4f455de3857bf8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T17:17:11Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-55b4a135031e4d249c4f455de3857bf82023-02-05T12:17:49ZengNature PortfolioNature Communications2041-17232023-02-0114111710.1038/s41467-023-36058-2The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular systemItika Saha0Patricia Yuste-Checa1Miguel Da Silva Padilha2Qiang Guo3Roman Körner4Hauke Holthusen5Victoria A. Trinkaus6Irina Dudanova7Rubén Fernández-Busnadiego8Wolfgang Baumeister9David W. Sanders10Saurabh Gautam11Marc I. Diamond12F. Ulrich Hartl13Mark S. Hipp14Department of Cellular Biochemistry, Max Planck Institute of BiochemistryDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryMolecular Neurodegeneration Group, Max Planck Institute for Biological IntelligenceDepartment of Structural Molecular Biology, Max Planck Institute of BiochemistryDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryMolecular Neurodegeneration Group, Max Planck Institute for Biological IntelligenceAligning Science Across Parkinson’s (ASAP) Collaborative Research NetworkDepartment of Structural Molecular Biology, Max Planck Institute of BiochemistryCenter for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical CenterDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryCenter for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical CenterDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryDepartment of Cellular Biochemistry, Max Planck Institute of BiochemistryTau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates seeding-active Tau species as byproduct.https://doi.org/10.1038/s41467-023-36058-2 |
| spellingShingle | Itika Saha Patricia Yuste-Checa Miguel Da Silva Padilha Qiang Guo Roman Körner Hauke Holthusen Victoria A. Trinkaus Irina Dudanova Rubén Fernández-Busnadiego Wolfgang Baumeister David W. Sanders Saurabh Gautam Marc I. Diamond F. Ulrich Hartl Mark S. Hipp The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system Nature Communications |
| title | The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system |
| title_full | The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system |
| title_fullStr | The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system |
| title_full_unstemmed | The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system |
| title_short | The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system |
| title_sort | aaa chaperone vcp disaggregates tau fibrils and generates aggregate seeds in a cellular system |
| url | https://doi.org/10.1038/s41467-023-36058-2 |
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