Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma
Lymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective lo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/9/5611 |
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| author | Carlos Navarro Cuéllar Ángela Sada Urmeneta Raquel Lorenzo Marcos Raúl Antúnez-Conde Ana López López José Luis del Castillo Pardo de Vera Javier González Martín-Moro José Luis Cebrián Carretero Francisco Alijo Serrano Giovanni Dell’Aversana Orabona Jose J. Zamorano-León Ignacio Navarro Cuéllar |
| author_facet | Carlos Navarro Cuéllar Ángela Sada Urmeneta Raquel Lorenzo Marcos Raúl Antúnez-Conde Ana López López José Luis del Castillo Pardo de Vera Javier González Martín-Moro José Luis Cebrián Carretero Francisco Alijo Serrano Giovanni Dell’Aversana Orabona Jose J. Zamorano-León Ignacio Navarro Cuéllar |
| author_sort | Carlos Navarro Cuéllar |
| collection | DOAJ |
| description | Lymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective longitudinal study with 62 patients was performed. All patients were diagnosed with LSCC and submitted for tumor resection and neck dissection. Patients were stratified into low (<0.04) and high risk (≥0.04) based on LND. We analyzed the impact of LND on overall survival (OS) and disease-free survival (DFS), as well as the relationship between LND and the pathological staging, the involvement of positive margins, depth of invasion (DOI) and perineural infiltration. This study provides a substantial relationship between lymph node density (LND), overall survival (OS) and disease-free survival (DFS) in lingual squamous cell carcinoma (LSCC). A statistically significant distribution was found between LND, perineural infiltration and pathological staging, whereas no association was found with the rest of the prognostic variables analyzed. |
| first_indexed | 2024-03-11T04:23:09Z |
| format | Article |
| id | doaj.art-55b52d1271394baa826f02998d0b871b |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T04:23:09Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-55b52d1271394baa826f02998d0b871b2023-11-17T22:36:26ZengMDPI AGApplied Sciences2076-34172023-05-01139561110.3390/app13095611Prognostic Value of Lymph Node Density in Lingual Squamous Cell CarcinomaCarlos Navarro Cuéllar0Ángela Sada Urmeneta1Raquel Lorenzo Marcos2Raúl Antúnez-Conde3Ana López López4José Luis del Castillo Pardo de Vera5Javier González Martín-Moro6José Luis Cebrián Carretero7Francisco Alijo Serrano8Giovanni Dell’Aversana Orabona9Jose J. Zamorano-León10Ignacio Navarro Cuéllar11Maxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario La Paz Madrid, P.º de la Castellana, 261, 28046 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario La Paz Madrid, P.º de la Castellana, 261, 28046 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario La Paz Madrid, P.º de la Castellana, 261, 28046 Madrid, SpainPathological Anatomy Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainMaxillofacial Surgery Department, Università “Federico II”, 80131 Naples, ItalyPublic Health and Maternal & Child Health Department, School of Medicine, Universidad Complutense, 28040 Madrid, SpainMaxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007 Madrid, SpainLymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective longitudinal study with 62 patients was performed. All patients were diagnosed with LSCC and submitted for tumor resection and neck dissection. Patients were stratified into low (<0.04) and high risk (≥0.04) based on LND. We analyzed the impact of LND on overall survival (OS) and disease-free survival (DFS), as well as the relationship between LND and the pathological staging, the involvement of positive margins, depth of invasion (DOI) and perineural infiltration. This study provides a substantial relationship between lymph node density (LND), overall survival (OS) and disease-free survival (DFS) in lingual squamous cell carcinoma (LSCC). A statistically significant distribution was found between LND, perineural infiltration and pathological staging, whereas no association was found with the rest of the prognostic variables analyzed.https://www.mdpi.com/2076-3417/13/9/5611oral cavity cancerlingual squamous cell carcinomalymph node densitypathological cervical lymphadenopathyneck dissectionperineural infiltration |
| spellingShingle | Carlos Navarro Cuéllar Ángela Sada Urmeneta Raquel Lorenzo Marcos Raúl Antúnez-Conde Ana López López José Luis del Castillo Pardo de Vera Javier González Martín-Moro José Luis Cebrián Carretero Francisco Alijo Serrano Giovanni Dell’Aversana Orabona Jose J. Zamorano-León Ignacio Navarro Cuéllar Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma Applied Sciences oral cavity cancer lingual squamous cell carcinoma lymph node density pathological cervical lymphadenopathy neck dissection perineural infiltration |
| title | Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma |
| title_full | Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma |
| title_fullStr | Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma |
| title_full_unstemmed | Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma |
| title_short | Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma |
| title_sort | prognostic value of lymph node density in lingual squamous cell carcinoma |
| topic | oral cavity cancer lingual squamous cell carcinoma lymph node density pathological cervical lymphadenopathy neck dissection perineural infiltration |
| url | https://www.mdpi.com/2076-3417/13/9/5611 |
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