Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies
Transcranial magnetic stimulation (TMS) is a promising treatment modality for psychiatric and neurological disorders. Repetitive TMS (rTMS) is widely used for the treatment of psychiatric and neurological diseases, such as depression, motor stroke, and neuropathic pain. However, the underlying mecha...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825205/full |
| _version_ | 1818025293006241792 |
|---|---|
| author | Yuki Mizutani-Tiebel Yuki Mizutani-Tiebel Martin Tik Kai-Yen Chang Kai-Yen Chang Frank Padberg Frank Padberg Aldo Soldini Aldo Soldini Aldo Soldini Zane Wilkinson Zane Wilkinson Cui Ci Voon Cui Ci Voon Lucia Bulubas Lucia Bulubas Lucia Bulubas Christian Windischberger Daniel Keeser Daniel Keeser Daniel Keeser |
| author_facet | Yuki Mizutani-Tiebel Yuki Mizutani-Tiebel Martin Tik Kai-Yen Chang Kai-Yen Chang Frank Padberg Frank Padberg Aldo Soldini Aldo Soldini Aldo Soldini Zane Wilkinson Zane Wilkinson Cui Ci Voon Cui Ci Voon Lucia Bulubas Lucia Bulubas Lucia Bulubas Christian Windischberger Daniel Keeser Daniel Keeser Daniel Keeser |
| author_sort | Yuki Mizutani-Tiebel |
| collection | DOAJ |
| description | Transcranial magnetic stimulation (TMS) is a promising treatment modality for psychiatric and neurological disorders. Repetitive TMS (rTMS) is widely used for the treatment of psychiatric and neurological diseases, such as depression, motor stroke, and neuropathic pain. However, the underlying mechanisms of rTMS-mediated neuronal modulation are not fully understood. In this respect, concurrent or simultaneous TMS-fMRI, in which TMS is applied during functional magnetic resonance imaging (fMRI), is a viable tool to gain insights, as it enables an investigation of the immediate effects of TMS. Concurrent application of TMS during neuroimaging usually causes severe artifacts due to magnetic field inhomogeneities induced by TMS. However, by carefully interleaving the TMS pulses with MR signal acquisition in the way that these are far enough apart, we can avoid any image distortions. While the very first feasibility studies date back to the 1990s, recent developments in coil hardware and acquisition techniques have boosted the number of TMS-fMRI applications. As such, a concurrent application requires expertise in both TMS and MRI mechanisms and sequencing, and the hurdle of initial technical set up and maintenance remains high. This review gives a comprehensive overview of concurrent TMS-fMRI techniques by collecting (1) basic information, (2) technical challenges and developments, (3) an overview of findings reported so far using concurrent TMS-fMRI, and (4) current limitations and our suggestions for improvement. By sharing this review, we hope to attract the interest of researchers from various backgrounds and create an educational knowledge base. |
| first_indexed | 2024-12-10T04:13:48Z |
| format | Article |
| id | doaj.art-55b5311a59454c139aaf662e1a23df13 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-10T04:13:48Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-55b5311a59454c139aaf662e1a23df132022-12-22T02:02:38ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.825205825205Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous StudiesYuki Mizutani-Tiebel0Yuki Mizutani-Tiebel1Martin Tik2Kai-Yen Chang3Kai-Yen Chang4Frank Padberg5Frank Padberg6Aldo Soldini7Aldo Soldini8Aldo Soldini9Zane Wilkinson10Zane Wilkinson11Cui Ci Voon12Cui Ci Voon13Lucia Bulubas14Lucia Bulubas15Lucia Bulubas16Christian Windischberger17Daniel Keeser18Daniel Keeser19Daniel Keeser20Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyHigh Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyInternational Max Planck Research School for Translational Psychiatry, Munich, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyInternational Max Planck Research School for Translational Psychiatry, Munich, GermanyHigh Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, GermanyNeuroimaging Core Unit Munich - NICUM, University Hospital LMU, Munich, GermanyDepartment of Radiology, University Hospital LMU, Munich, GermanyTranscranial magnetic stimulation (TMS) is a promising treatment modality for psychiatric and neurological disorders. Repetitive TMS (rTMS) is widely used for the treatment of psychiatric and neurological diseases, such as depression, motor stroke, and neuropathic pain. However, the underlying mechanisms of rTMS-mediated neuronal modulation are not fully understood. In this respect, concurrent or simultaneous TMS-fMRI, in which TMS is applied during functional magnetic resonance imaging (fMRI), is a viable tool to gain insights, as it enables an investigation of the immediate effects of TMS. Concurrent application of TMS during neuroimaging usually causes severe artifacts due to magnetic field inhomogeneities induced by TMS. However, by carefully interleaving the TMS pulses with MR signal acquisition in the way that these are far enough apart, we can avoid any image distortions. While the very first feasibility studies date back to the 1990s, recent developments in coil hardware and acquisition techniques have boosted the number of TMS-fMRI applications. As such, a concurrent application requires expertise in both TMS and MRI mechanisms and sequencing, and the hurdle of initial technical set up and maintenance remains high. This review gives a comprehensive overview of concurrent TMS-fMRI techniques by collecting (1) basic information, (2) technical challenges and developments, (3) an overview of findings reported so far using concurrent TMS-fMRI, and (4) current limitations and our suggestions for improvement. By sharing this review, we hope to attract the interest of researchers from various backgrounds and create an educational knowledge base.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825205/fullconcurrent TMS-fMRIinterleaved TMS-fMRIfunctional MRI (fMRI)transcranial magnetic stimulation (TMS)review |
| spellingShingle | Yuki Mizutani-Tiebel Yuki Mizutani-Tiebel Martin Tik Kai-Yen Chang Kai-Yen Chang Frank Padberg Frank Padberg Aldo Soldini Aldo Soldini Aldo Soldini Zane Wilkinson Zane Wilkinson Cui Ci Voon Cui Ci Voon Lucia Bulubas Lucia Bulubas Lucia Bulubas Christian Windischberger Daniel Keeser Daniel Keeser Daniel Keeser Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies Frontiers in Psychiatry concurrent TMS-fMRI interleaved TMS-fMRI functional MRI (fMRI) transcranial magnetic stimulation (TMS) review |
| title | Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies |
| title_full | Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies |
| title_fullStr | Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies |
| title_full_unstemmed | Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies |
| title_short | Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies |
| title_sort | concurrent tms fmri technical challenges developments and overview of previous studies |
| topic | concurrent TMS-fMRI interleaved TMS-fMRI functional MRI (fMRI) transcranial magnetic stimulation (TMS) review |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825205/full |
| work_keys_str_mv | AT yukimizutanitiebel concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT yukimizutanitiebel concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT martintik concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT kaiyenchang concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT kaiyenchang concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT frankpadberg concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT frankpadberg concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT aldosoldini concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT aldosoldini concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT aldosoldini concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT zanewilkinson concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT zanewilkinson concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT cuicivoon concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT cuicivoon concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT luciabulubas concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT luciabulubas concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT luciabulubas concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT christianwindischberger concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT danielkeeser concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT danielkeeser concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies AT danielkeeser concurrenttmsfmritechnicalchallengesdevelopmentsandoverviewofpreviousstudies |