Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review
Abstract A complex of G719X and S768I mutations is infrequently observed, constituting less than 0.3% of all EGFR‐positive non‐small cell lung cancer (NSCLC), and the response to first‐line TKIs is inconsistent in the literature. In this study, we report a patient with metastatic non‐small cell lung...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1131 |
| _version_ | 1797839725621411840 |
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| author | Kien Hung Do Duc Thanh Le Tai Van Nguyen Tu Anh Do Chu Van Nguyen |
| author_facet | Kien Hung Do Duc Thanh Le Tai Van Nguyen Tu Anh Do Chu Van Nguyen |
| author_sort | Kien Hung Do |
| collection | DOAJ |
| description | Abstract A complex of G719X and S768I mutations is infrequently observed, constituting less than 0.3% of all EGFR‐positive non‐small cell lung cancer (NSCLC), and the response to first‐line TKIs is inconsistent in the literature. In this study, we report a patient with metastatic non‐small cell lung cancer carrying rare EGFR compound mutations of G719X and S768I who benefited from first‐line treatment with gefitinib in Vietnam. This patient had a prolonged response lasting over 44 months with first‐generation TKI. He continued to take gefitinib without experiencing serious adverse events. NSCLC with a rare complex of G719X and S768I mutation revealed a good response to gefitinib. |
| first_indexed | 2024-04-09T16:01:41Z |
| format | Article |
| id | doaj.art-55b592de4abc4787874ec8b7836ae75b |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-04-09T16:01:41Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-55b592de4abc4787874ec8b7836ae75b2023-04-25T09:44:35ZengWileyRespirology Case Reports2051-33802023-05-01115n/an/a10.1002/rcr2.1131Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature reviewKien Hung Do0Duc Thanh Le1Tai Van Nguyen2Tu Anh Do3Chu Van Nguyen4National Cancer Hospital Hanoi VietnamNational Cancer Hospital Hanoi VietnamNational Cancer Hospital Hanoi VietnamNational Cancer Hospital Hanoi VietnamNational Cancer Hospital Hanoi VietnamAbstract A complex of G719X and S768I mutations is infrequently observed, constituting less than 0.3% of all EGFR‐positive non‐small cell lung cancer (NSCLC), and the response to first‐line TKIs is inconsistent in the literature. In this study, we report a patient with metastatic non‐small cell lung cancer carrying rare EGFR compound mutations of G719X and S768I who benefited from first‐line treatment with gefitinib in Vietnam. This patient had a prolonged response lasting over 44 months with first‐generation TKI. He continued to take gefitinib without experiencing serious adverse events. NSCLC with a rare complex of G719X and S768I mutation revealed a good response to gefitinib.https://doi.org/10.1002/rcr2.1131first‐generation TKIsG719X and S768I mutationsNSCLCrare EGFR mutation |
| spellingShingle | Kien Hung Do Duc Thanh Le Tai Van Nguyen Tu Anh Do Chu Van Nguyen Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review Respirology Case Reports first‐generation TKIs G719X and S768I mutations NSCLC rare EGFR mutation |
| title | Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review |
| title_full | Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review |
| title_fullStr | Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review |
| title_full_unstemmed | Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review |
| title_short | Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review |
| title_sort | prolonged response to first generation tyrosine kinase inhibitor in a metastatic non small cell lung cancer harbouring complex g719x and s768i mutations a case report from vietnam and literature review |
| topic | first‐generation TKIs G719X and S768I mutations NSCLC rare EGFR mutation |
| url | https://doi.org/10.1002/rcr2.1131 |
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