An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance
Premature birth bears an increased risk for aberrant brain development concerning its structure and function. Cortical complexity (CC) expresses the fractal dimension of the brain surface and changes during neurodevelopment. We hypothesized that CC is altered after premature birth and associated wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811919310298 |
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| author | Dennis M. Hedderich Josef G. Bäuml Aurore Menegaux Mihai Avram Marcel Daamen Claus Zimmer Peter Bartmann Lukas Scheef Henning Boecker Dieter Wolke Christian Gaser Christian Sorg |
| author_facet | Dennis M. Hedderich Josef G. Bäuml Aurore Menegaux Mihai Avram Marcel Daamen Claus Zimmer Peter Bartmann Lukas Scheef Henning Boecker Dieter Wolke Christian Gaser Christian Sorg |
| author_sort | Dennis M. Hedderich |
| collection | DOAJ |
| description | Premature birth bears an increased risk for aberrant brain development concerning its structure and function. Cortical complexity (CC) expresses the fractal dimension of the brain surface and changes during neurodevelopment. We hypothesized that CC is altered after premature birth and associated with long-term cognitive development.One-hundred-and-one very premature-born adults (gestational age <32 weeks and/or birth weight <1500 g) and 111 term-born adults were assessed by structural MRI and cognitive testing at 26 years of age. CC was measured based on MRI by vertex-wise estimation of fractal dimension. Cognitive performance was measured based on Griffiths-Mental-Development-Scale (at 20 months) and Wechsler-Adult-Intelligence-Scales (at 26 years).In premature-born adults, CC was decreased bilaterally in large lateral temporal and medial parietal clusters. Decreased CC was associated with lower gestational age and birth weight. Furthermore, decreased CC in the medial parietal cortices was linked with reduced full-scale IQ of premature-born adults and mediated the association between cognitive development at 20 months and IQ in adulthood.Results demonstrate that CC is reduced in very premature-born adults in temporoparietal cortices, mediating the impact of prematurity on impaired cognitive development. These data indicate functionally relevant long-term alterations in the brain’s basic geometry of cortical organization in prematurity. |
| first_indexed | 2024-12-12T22:56:46Z |
| format | Article |
| id | doaj.art-55b6e615d38349cf85fa4f212edc032a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-12T22:56:46Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-55b6e615d38349cf85fa4f212edc032a2022-12-22T00:08:55ZengElsevierNeuroImage1095-95722020-03-01208116438An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significanceDennis M. Hedderich0Josef G. Bäuml1Aurore Menegaux2Mihai Avram3Marcel Daamen4Claus Zimmer5Peter Bartmann6Lukas Scheef7Henning Boecker8Dieter Wolke9Christian Gaser10Christian Sorg11Department of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, Germany; Corresponding author. Technical University of Munich, School of Medicine, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany. Tel.: 0049 89 4140 4652; Fax: 0049 89 4140 4653.Department of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, GermanyFunctional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, Germany; Department of Neonatology, University Hospital Bonn, Bonn, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, GermanyDepartment of Neonatology, University Hospital Bonn, Bonn, GermanyFunctional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, GermanyFunctional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, GermanyDepartment of Psychology, University of Warwick, Coventry, UK; Warwick Medical School, University of Warwick, Coventry, UKDepartment of Neurology, Jena University Hospital, Jena, Germany; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; TUM-NIC Neuroimaging Center, Germany; Department of Psychiatry, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, GermanyPremature birth bears an increased risk for aberrant brain development concerning its structure and function. Cortical complexity (CC) expresses the fractal dimension of the brain surface and changes during neurodevelopment. We hypothesized that CC is altered after premature birth and associated with long-term cognitive development.One-hundred-and-one very premature-born adults (gestational age <32 weeks and/or birth weight <1500 g) and 111 term-born adults were assessed by structural MRI and cognitive testing at 26 years of age. CC was measured based on MRI by vertex-wise estimation of fractal dimension. Cognitive performance was measured based on Griffiths-Mental-Development-Scale (at 20 months) and Wechsler-Adult-Intelligence-Scales (at 26 years).In premature-born adults, CC was decreased bilaterally in large lateral temporal and medial parietal clusters. Decreased CC was associated with lower gestational age and birth weight. Furthermore, decreased CC in the medial parietal cortices was linked with reduced full-scale IQ of premature-born adults and mediated the association between cognitive development at 20 months and IQ in adulthood.Results demonstrate that CC is reduced in very premature-born adults in temporoparietal cortices, mediating the impact of prematurity on impaired cognitive development. These data indicate functionally relevant long-term alterations in the brain’s basic geometry of cortical organization in prematurity.http://www.sciencedirect.com/science/article/pii/S1053811919310298Magnetic resonance imagingFractal dimensionCortical complexityPremature birthBrain development |
| spellingShingle | Dennis M. Hedderich Josef G. Bäuml Aurore Menegaux Mihai Avram Marcel Daamen Claus Zimmer Peter Bartmann Lukas Scheef Henning Boecker Dieter Wolke Christian Gaser Christian Sorg An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance NeuroImage Magnetic resonance imaging Fractal dimension Cortical complexity Premature birth Brain development |
| title | An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance |
| title_full | An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance |
| title_fullStr | An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance |
| title_full_unstemmed | An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance |
| title_short | An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance |
| title_sort | analysis of mri derived cortical complexity in premature born adults regional patterns risk factors and potential significance |
| topic | Magnetic resonance imaging Fractal dimension Cortical complexity Premature birth Brain development |
| url | http://www.sciencedirect.com/science/article/pii/S1053811919310298 |
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