Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review
The past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/23/11565 |
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| author | Mihai Octavian Negrea Bogdan Neamtu Ioana Dobrotă Ciprian Radu Sofariu Roxana Mihaela Crisan Bacila Ionut Ciprian Carmen Daniela Domnariu Minodora Teodoru |
| author_facet | Mihai Octavian Negrea Bogdan Neamtu Ioana Dobrotă Ciprian Radu Sofariu Roxana Mihaela Crisan Bacila Ionut Ciprian Carmen Daniela Domnariu Minodora Teodoru |
| author_sort | Mihai Octavian Negrea |
| collection | DOAJ |
| description | The past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obesity. This is a particularly concerning aspect when considering the well-established link between cardiovascular disease and obesity, and the fact that childhood obesity frequently leads to adult obesity. Moreover, most obese adults have a history of excess weight starting in childhood. In addition, given the cumulative character of both time and severity of exposure to obesity as a risk factor for associated diseases, the repercussions of obesity prevalence and related morbidity could be exponential in time. The purpose of this review is to outline key aspects regarding the current knowledge on childhood and adolescent obesity as a cardiometabolic risk factor, as well as the most common etiological pathways involved in the development of weight excess and associated cardiovascular and metabolic diseases. |
| first_indexed | 2024-03-10T04:56:07Z |
| format | Article |
| id | doaj.art-55b789dc08d74633a48b87b5cd0d6fcf |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T04:56:07Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-55b789dc08d74633a48b87b5cd0d6fcf2023-11-23T02:10:29ZengMDPI AGApplied Sciences2076-34172021-12-0111231156510.3390/app112311565Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature ReviewMihai Octavian Negrea0Bogdan Neamtu1Ioana Dobrotă2Ciprian Radu Sofariu3Roxana Mihaela Crisan4Bacila Ionut Ciprian5Carmen Daniela Domnariu6Minodora Teodoru7Faculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaResearch and Telemedicine Center for Neurological Diseases in Children, Pediatric Clinical Hospital Sibiu, 550166 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University, 550024 Sibiu, RomaniaThe past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obesity. This is a particularly concerning aspect when considering the well-established link between cardiovascular disease and obesity, and the fact that childhood obesity frequently leads to adult obesity. Moreover, most obese adults have a history of excess weight starting in childhood. In addition, given the cumulative character of both time and severity of exposure to obesity as a risk factor for associated diseases, the repercussions of obesity prevalence and related morbidity could be exponential in time. The purpose of this review is to outline key aspects regarding the current knowledge on childhood and adolescent obesity as a cardiometabolic risk factor, as well as the most common etiological pathways involved in the development of weight excess and associated cardiovascular and metabolic diseases.https://www.mdpi.com/2076-3417/11/23/11565childhood obesitypathophysiologyrisk factors |
| spellingShingle | Mihai Octavian Negrea Bogdan Neamtu Ioana Dobrotă Ciprian Radu Sofariu Roxana Mihaela Crisan Bacila Ionut Ciprian Carmen Daniela Domnariu Minodora Teodoru Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review Applied Sciences childhood obesity pathophysiology risk factors |
| title | Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review |
| title_full | Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review |
| title_fullStr | Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review |
| title_full_unstemmed | Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review |
| title_short | Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review |
| title_sort | causative mechanisms of childhood and adolescent obesity leading to adult cardiometabolic disease a literature review |
| topic | childhood obesity pathophysiology risk factors |
| url | https://www.mdpi.com/2076-3417/11/23/11565 |
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