Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy
Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, relapsing, sterile pustular eruption of unknown etiology that develops most commonly in middle-aged or mature women. This article reviews the presentation, associations, and management of the condition and high...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2020-06-01
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| Series: | International Journal of Women's Dermatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352647520300125 |
| _version_ | 1798018314529669120 |
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| author | Shashank Bhargava, MD Ujjwal Kumar, MD George Kroumpouzos, MD, PhD |
| author_facet | Shashank Bhargava, MD Ujjwal Kumar, MD George Kroumpouzos, MD, PhD |
| author_sort | Shashank Bhargava, MD |
| collection | DOAJ |
| description | Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, relapsing, sterile pustular eruption of unknown etiology that develops most commonly in middle-aged or mature women. This article reviews the presentation, associations, and management of the condition and highlights advances in pathophysiology. Onset of SPD during pregnancy has not been reported. Herein, we report a case of SPD that developed during pregnancy. The patient was treated with dapsone without complications for her or the fetus. An association between T helper (Th) 17 and Th2 environments in the development of SPD has been advocated. Pregnancy is characterized by a predominance of Th2 responses and increased interleukin-17 levels and thus may favor the development of the condition |
| first_indexed | 2024-04-11T16:22:07Z |
| format | Article |
| id | doaj.art-55b833ac57a745229299aa5130f34fc1 |
| institution | Directory Open Access Journal |
| issn | 2352-6475 |
| language | English |
| last_indexed | 2024-04-11T16:22:07Z |
| publishDate | 2020-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | International Journal of Women's Dermatology |
| spelling | doaj.art-55b833ac57a745229299aa5130f34fc12022-12-22T04:14:18ZengWolters KluwerInternational Journal of Women's Dermatology2352-64752020-06-0163131136Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapyShashank Bhargava, MD0Ujjwal Kumar, MD1George Kroumpouzos, MD, PhD2Department of Dermatology, R.D. Gardi Medical College, Ujjain, IndiaDepartment of Dermatology, R.D. Gardi Medical College, Ujjain, IndiaDepartment of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, India; GK Dermatology, PC, S Weymouth, Massachusetts, United States; Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil; Corresponding author at: Department of Dermatology, R.D. Gardi Medical College, Ujjain, India.Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, relapsing, sterile pustular eruption of unknown etiology that develops most commonly in middle-aged or mature women. This article reviews the presentation, associations, and management of the condition and highlights advances in pathophysiology. Onset of SPD during pregnancy has not been reported. Herein, we report a case of SPD that developed during pregnancy. The patient was treated with dapsone without complications for her or the fetus. An association between T helper (Th) 17 and Th2 environments in the development of SPD has been advocated. Pregnancy is characterized by a predominance of Th2 responses and increased interleukin-17 levels and thus may favor the development of the conditionhttp://www.sciencedirect.com/science/article/pii/S2352647520300125Subcorneal pustular dermatosisSneddon-Wilkinson diseaseNeutrophilic dermatosisPregnancyDapsoneGestation |
| spellingShingle | Shashank Bhargava, MD Ujjwal Kumar, MD George Kroumpouzos, MD, PhD Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy International Journal of Women's Dermatology Subcorneal pustular dermatosis Sneddon-Wilkinson disease Neutrophilic dermatosis Pregnancy Dapsone Gestation |
| title | Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy |
| title_full | Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy |
| title_fullStr | Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy |
| title_full_unstemmed | Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy |
| title_short | Subcorneal pustular dermatosis: Comprehensive review and report of a case presenting during pregnancytherapy |
| title_sort | subcorneal pustular dermatosis comprehensive review and report of a case presenting during pregnancytherapy |
| topic | Subcorneal pustular dermatosis Sneddon-Wilkinson disease Neutrophilic dermatosis Pregnancy Dapsone Gestation |
| url | http://www.sciencedirect.com/science/article/pii/S2352647520300125 |
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