Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia
Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual influenza vaccination. Eighty older institut...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622001053 |
| _version_ | 1797991275886018560 |
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| author | Mirjam Münch Rolf Goldbach Naomi Zumstein Petra Vonmoos Jean-Louis Scartezzini Anna Wirz-Justice Christian Cajochen |
| author_facet | Mirjam Münch Rolf Goldbach Naomi Zumstein Petra Vonmoos Jean-Louis Scartezzini Anna Wirz-Justice Christian Cajochen |
| author_sort | Mirjam Münch |
| collection | DOAJ |
| description | Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual influenza vaccination. Eighty older institutionalised patients suffering from dementia (54 women and 26 men) continuously wore an activity tracker for 8 weeks to assess individual light exposure and rest-activity cycles. We analysed the patients’ immune response from two blood samples taken before and 4 weeks after the annual influenza vaccination. Individual antibody concentrations to three influenza virus strains (H3N2, H1N1, IB) were quantified via hemagglutination inhibition assays. By quantifying individual light exposure profiles (including daylight), we classified the patients into a low and a high light exposure group based on a median illuminance of 392.6 lux. The two light exposure groups did not differ in cognitive impairment severity, age or gender distribution. However, patients in the high light exposure group showed a significantly greater circadian rest-activity amplitude (i.e., more daytime activity and less nighttime activity) along with a significantly greater antibody titer increase to the H3N2 vaccine than patients in the low light exposure group, despite similar pre-vaccination concentrations. Sufficient seroprotective responses to all three influenza virus strains were attained for ≥75% of participants. These data provide preliminary evidence for a potentially enhanced immune response in patients with dementia when they received more daily light. Future studies are needed to determine whether regular daily light exposure may have beneficial effects on the human immune system, either directly or via a stabilising circadian sleep-wake rhythms. |
| first_indexed | 2024-04-11T08:49:32Z |
| format | Article |
| id | doaj.art-55b8f860b8f74814b03d48245d0f1743 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-11T08:49:32Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-55b8f860b8f74814b03d48245d0f17432022-12-22T04:33:37ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-12-0126100515Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementiaMirjam Münch0Rolf Goldbach1Naomi Zumstein2Petra Vonmoos3Jean-Louis Scartezzini4Anna Wirz-Justice5Christian Cajochen6Solar Energy and Building Physics Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland; Transfaculty Research Platform, Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland; Corresponding author. Centre for Chronobiology Psychiatric Hospital of the University of Basel, Basel, Switzerland Transfaculty Research Platform Molecular and Cognitive Neurosciences University of Basel, Switzerland Wilhelm Klein-Strasse 27, CH-4002, Basel, Switzerland.Geriatric Service of the City of Zurich, Zurich, SwitzerlandDepartment of Anthropology, McGill University, Montreal, Canada; University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Zurich, SwitzerlandSonnweid – the Home, Wetzikon, SwitzerlandSolar Energy and Building Physics Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, SwitzerlandCentre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland; Transfaculty Research Platform, Molecular and Cognitive Neurosciences, University of Basel, Basel, SwitzerlandEnhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual influenza vaccination. Eighty older institutionalised patients suffering from dementia (54 women and 26 men) continuously wore an activity tracker for 8 weeks to assess individual light exposure and rest-activity cycles. We analysed the patients’ immune response from two blood samples taken before and 4 weeks after the annual influenza vaccination. Individual antibody concentrations to three influenza virus strains (H3N2, H1N1, IB) were quantified via hemagglutination inhibition assays. By quantifying individual light exposure profiles (including daylight), we classified the patients into a low and a high light exposure group based on a median illuminance of 392.6 lux. The two light exposure groups did not differ in cognitive impairment severity, age or gender distribution. However, patients in the high light exposure group showed a significantly greater circadian rest-activity amplitude (i.e., more daytime activity and less nighttime activity) along with a significantly greater antibody titer increase to the H3N2 vaccine than patients in the low light exposure group, despite similar pre-vaccination concentrations. Sufficient seroprotective responses to all three influenza virus strains were attained for ≥75% of participants. These data provide preliminary evidence for a potentially enhanced immune response in patients with dementia when they received more daily light. Future studies are needed to determine whether regular daily light exposure may have beneficial effects on the human immune system, either directly or via a stabilising circadian sleep-wake rhythms.http://www.sciencedirect.com/science/article/pii/S2666354622001053ImmunologyFlu shotCircadianLightNeurodegenerationRest-activity |
| spellingShingle | Mirjam Münch Rolf Goldbach Naomi Zumstein Petra Vonmoos Jean-Louis Scartezzini Anna Wirz-Justice Christian Cajochen Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia Brain, Behavior, & Immunity - Health Immunology Flu shot Circadian Light Neurodegeneration Rest-activity |
| title | Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| title_full | Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| title_fullStr | Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| title_full_unstemmed | Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| title_short | Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| title_sort | preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia |
| topic | Immunology Flu shot Circadian Light Neurodegeneration Rest-activity |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622001053 |
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