Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis
Obesity confers an independent risk for carcinogenesis. Classically viewed as a genetic disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone are not sufficient to explain the progression and development of cancers. Tumor development is often associated with metabo...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.958696/full |
| _version_ | 1811243185891966976 |
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| author | Taojian Tu Mario M. Alba Aditi A. Datta Handan Hong Brittney Hua Yunyi Jia Jared Khan Phillip Nguyen Xiatoeng Niu Pranav Pammidimukkala Ielyzaveta Slarve Qi Tang Chenxi Xu Yiren Zhou Bangyan L. Stiles Bangyan L. Stiles |
| author_facet | Taojian Tu Mario M. Alba Aditi A. Datta Handan Hong Brittney Hua Yunyi Jia Jared Khan Phillip Nguyen Xiatoeng Niu Pranav Pammidimukkala Ielyzaveta Slarve Qi Tang Chenxi Xu Yiren Zhou Bangyan L. Stiles Bangyan L. Stiles |
| author_sort | Taojian Tu |
| collection | DOAJ |
| description | Obesity confers an independent risk for carcinogenesis. Classically viewed as a genetic disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone are not sufficient to explain the progression and development of cancers. Tumor development is often associated with metabolic and immunological changes. In particular, obesity is found to significantly increase the mortality rate of liver cancer. As its role is not defined, a fundamental question is whether and how metabolic changes drive the development of cancer. In this review, we will dissect the current literature demonstrating that liver lipid dysfunction is a critical component driving the progression of cancer. We will discuss the involvement of inflammation in lipid dysfunction driven liver cancer development with a focus on the involvement of liver macrophages. We will first discuss the association of steatosis with liver cancer. This will be followed with a literature summary demonstrating the importance of inflammation and particularly macrophages in the progression of liver steatosis and highlighting the evidence that macrophages and macrophage produced inflammatory mediators are critical for liver cancer development. We will then discuss the specific inflammatory mediators and their roles in steatosis driven liver cancer development. Finally, we will summarize the molecular pattern (PAMP and DAMP) as well as lipid particle signals that are involved in the activation, infiltration and reprogramming of liver macrophages. We will also discuss some of the therapies that may interfere with lipid metabolism and also affect liver cancer development. |
| first_indexed | 2024-04-12T14:02:59Z |
| format | Article |
| id | doaj.art-55ba334f1c884f55b8521a34fc833786 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T14:02:59Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-55ba334f1c884f55b8521a34fc8337862022-12-22T03:30:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.958696958696Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesisTaojian Tu0Mario M. Alba1Aditi A. Datta2Handan Hong3Brittney Hua4Yunyi Jia5Jared Khan6Phillip Nguyen7Xiatoeng Niu8Pranav Pammidimukkala9Ielyzaveta Slarve10Qi Tang11Chenxi Xu12Yiren Zhou13Bangyan L. Stiles14Bangyan L. Stiles15Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United StatesDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesObesity confers an independent risk for carcinogenesis. Classically viewed as a genetic disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone are not sufficient to explain the progression and development of cancers. Tumor development is often associated with metabolic and immunological changes. In particular, obesity is found to significantly increase the mortality rate of liver cancer. As its role is not defined, a fundamental question is whether and how metabolic changes drive the development of cancer. In this review, we will dissect the current literature demonstrating that liver lipid dysfunction is a critical component driving the progression of cancer. We will discuss the involvement of inflammation in lipid dysfunction driven liver cancer development with a focus on the involvement of liver macrophages. We will first discuss the association of steatosis with liver cancer. This will be followed with a literature summary demonstrating the importance of inflammation and particularly macrophages in the progression of liver steatosis and highlighting the evidence that macrophages and macrophage produced inflammatory mediators are critical for liver cancer development. We will then discuss the specific inflammatory mediators and their roles in steatosis driven liver cancer development. Finally, we will summarize the molecular pattern (PAMP and DAMP) as well as lipid particle signals that are involved in the activation, infiltration and reprogramming of liver macrophages. We will also discuss some of the therapies that may interfere with lipid metabolism and also affect liver cancer development.https://www.frontiersin.org/articles/10.3389/fonc.2022.958696/fullmacrophagesKupffer Cellssteatosisliver cancerinflammation |
| spellingShingle | Taojian Tu Mario M. Alba Aditi A. Datta Handan Hong Brittney Hua Yunyi Jia Jared Khan Phillip Nguyen Xiatoeng Niu Pranav Pammidimukkala Ielyzaveta Slarve Qi Tang Chenxi Xu Yiren Zhou Bangyan L. Stiles Bangyan L. Stiles Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis Frontiers in Oncology macrophages Kupffer Cells steatosis liver cancer inflammation |
| title | Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| title_full | Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| title_fullStr | Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| title_full_unstemmed | Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| title_short | Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| title_sort | hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis |
| topic | macrophages Kupffer Cells steatosis liver cancer inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.958696/full |
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