Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a hematological disease characterized by the dysfunction of the hematopoietic system that leads to arrest at a specific stage of stem cells development, suppressing the average production of cellular hematologic components. BCP-ALL is a neoplasm of the B-cell li...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/16/4186 |
| _version_ | 1797585174897098752 |
|---|---|
| author | Claudia Daniela Álvarez-Zúñiga Idalia Garza-Veloz Jacqueline Martínez-Rendón Misael Ureño-Segura Iván Delgado-Enciso Margarita L. Martinez-Fierro |
| author_facet | Claudia Daniela Álvarez-Zúñiga Idalia Garza-Veloz Jacqueline Martínez-Rendón Misael Ureño-Segura Iván Delgado-Enciso Margarita L. Martinez-Fierro |
| author_sort | Claudia Daniela Álvarez-Zúñiga |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is a hematological disease characterized by the dysfunction of the hematopoietic system that leads to arrest at a specific stage of stem cells development, suppressing the average production of cellular hematologic components. BCP-ALL is a neoplasm of the B-cell lineage progenitor. BCP-ALL is caused and perpetuated by several mechanisms that provide the disease with its tumor potential and genetic and cytological characteristics. These pathological features are used for diagnosis and the prognostication of BCP-ALL. However, most of these paraclinical tools can only be obtained by bone marrow aspiration, which, as it is an invasive study, can delay the diagnosis and follow-up of the disease, in addition to the anesthetic risk it entails for pediatric patients. For this reason, it is crucial to find noninvasive and accessible ways to supply information concerning diagnosis, prognosis, and the monitoring of the disease, such as circulating biomarkers. In oncology, a biomarker is any measurable indicator that demonstrates the presence of malignancy, tumoral behavior, prognosis, or responses to treatments. This review summarizes circulating molecules associated with BCP-ALL with potential diagnostic value, classificatory capacity during monitoring specific clinic features of the disease, and/or capacity to identify each BCP-ALL stage regarding its evolution and outcome of the patients with BCP-ALL. In the same way, we provide and classify biomarkers that may be used in further studies focused on clinical approaches or therapeutic target identification for BCP-ALL. |
| first_indexed | 2024-03-11T00:03:14Z |
| format | Article |
| id | doaj.art-55baad16baf44b4a80bd469a4bb732aa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:03:14Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-55baad16baf44b4a80bd469a4bb732aa2023-11-19T00:34:36ZengMDPI AGCancers2072-66942023-08-011516418610.3390/cancers15164186Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic LeukemiaClaudia Daniela Álvarez-Zúñiga0Idalia Garza-Veloz1Jacqueline Martínez-Rendón2Misael Ureño-Segura3Iván Delgado-Enciso4Margarita L. Martinez-Fierro5Molecular Medicine Laboratory, Unidad Académica de Medicina Humana y C.S, Universidad Autónoma de Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Unidad Académica de Medicina Humana y C.S, Universidad Autónoma de Zacatecas, Zacatecas 98160, MexicoMolecular Medicine Laboratory, Unidad Académica de Medicina Humana y C.S, Universidad Autónoma de Zacatecas, Zacatecas 98160, MexicoHematology Service, Hospital General Zacatecas “Luz González Cosío”, Servicios de Salud de Zacatecas, Zacatecas 98160, MexicoCancerology State Institute, Colima State Health Services, Colima 28085, MexicoMolecular Medicine Laboratory, Unidad Académica de Medicina Humana y C.S, Universidad Autónoma de Zacatecas, Zacatecas 98160, MexicoAcute lymphoblastic leukemia (ALL) is a hematological disease characterized by the dysfunction of the hematopoietic system that leads to arrest at a specific stage of stem cells development, suppressing the average production of cellular hematologic components. BCP-ALL is a neoplasm of the B-cell lineage progenitor. BCP-ALL is caused and perpetuated by several mechanisms that provide the disease with its tumor potential and genetic and cytological characteristics. These pathological features are used for diagnosis and the prognostication of BCP-ALL. However, most of these paraclinical tools can only be obtained by bone marrow aspiration, which, as it is an invasive study, can delay the diagnosis and follow-up of the disease, in addition to the anesthetic risk it entails for pediatric patients. For this reason, it is crucial to find noninvasive and accessible ways to supply information concerning diagnosis, prognosis, and the monitoring of the disease, such as circulating biomarkers. In oncology, a biomarker is any measurable indicator that demonstrates the presence of malignancy, tumoral behavior, prognosis, or responses to treatments. This review summarizes circulating molecules associated with BCP-ALL with potential diagnostic value, classificatory capacity during monitoring specific clinic features of the disease, and/or capacity to identify each BCP-ALL stage regarding its evolution and outcome of the patients with BCP-ALL. In the same way, we provide and classify biomarkers that may be used in further studies focused on clinical approaches or therapeutic target identification for BCP-ALL.https://www.mdpi.com/2072-6694/15/16/4186biomarkerscirculatingacute lymphoblastic leukemiaBCP-ALLdiagnosisprognosis |
| spellingShingle | Claudia Daniela Álvarez-Zúñiga Idalia Garza-Veloz Jacqueline Martínez-Rendón Misael Ureño-Segura Iván Delgado-Enciso Margarita L. Martinez-Fierro Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia Cancers biomarkers circulating acute lymphoblastic leukemia BCP-ALL diagnosis prognosis |
| title | Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia |
| title_full | Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia |
| title_fullStr | Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia |
| title_short | Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia |
| title_sort | circulating biomarkers associated with the diagnosis and prognosis of b cell progenitor acute lymphoblastic leukemia |
| topic | biomarkers circulating acute lymphoblastic leukemia BCP-ALL diagnosis prognosis |
| url | https://www.mdpi.com/2072-6694/15/16/4186 |
| work_keys_str_mv | AT claudiadanielaalvarezzuniga circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia AT idaliagarzaveloz circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia AT jacquelinemartinezrendon circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia AT misaelurenosegura circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia AT ivandelgadoenciso circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia AT margaritalmartinezfierro circulatingbiomarkersassociatedwiththediagnosisandprognosisofbcellprogenitoracutelymphoblasticleukemia |