Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study
Antiphospholipid antibodies are highly prevalent in autoimmune diseases and mainly associated with thromboembolic events, which is one of the major reasons for cancer-related mortality. Confirmed adult cancer patients were included (n = 40) with an equal number of age- and sex-matched healthy contro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/7/2087 |
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| author | Md. Ashraful Islam Nipu Shoumik Kundu Sayeda Sadia Alam Ashrafun Naher Dina Md. Ashraful Hasan Mohammad Khan Md. Ibrahim Khalil Tareq Hossan Md Asiful Islam |
| author_facet | Md. Ashraful Islam Nipu Shoumik Kundu Sayeda Sadia Alam Ashrafun Naher Dina Md. Ashraful Hasan Mohammad Khan Md. Ibrahim Khalil Tareq Hossan Md Asiful Islam |
| author_sort | Md. Ashraful Islam Nipu |
| collection | DOAJ |
| description | Antiphospholipid antibodies are highly prevalent in autoimmune diseases and mainly associated with thromboembolic events, which is one of the major reasons for cancer-related mortality. Confirmed adult cancer patients were included (n = 40) with an equal number of age- and sex-matched healthy controls. The presence and concentration of anticardiolipin antibodies were investigated by the enzyme-linked immunosorbent assay using the venous blood samples. aCL antibodies were detected in 60.0% (n = 24) of the cancer patients compared to none in the healthy controls (<i>p</i> < 0.001). The serum concentration of aCL antibodies was significantly higher in cancer patients than controls (<i>p</i> < 0.001) and ranged from 89.0 U/mL to 133.0 U/mL among the aCL-positive patients. All the lung cancer patients (n = 6) were diagnosed with positive aCL, and a borderline significant association of aCL antibody positivity was observed in colon cancer patients (<i>p</i> = 0.051). About 72.7% of the advanced-stage cancer individuals and 81.8% of the cancer patients who underwent surgery were diagnosed with positive aCL antibodies. A significant association of aCL antibody positivity was observed with cancer patients comorbid with heart diseases (<i>p</i> = 0.005). The prevalence and serum levels of aCL antibodies were significantly higher in cancer patients compared to healthy controls. Cancer patients (i.e., lung, liver, and colon), at advanced-stage, comorbid with heart diseases, who underwent surgery, were more likely to be diagnosed with aCL antibodies. |
| first_indexed | 2024-03-11T05:40:43Z |
| format | Article |
| id | doaj.art-55baaedf2d7841eb9daaf2e135d3f0f9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:40:43Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-55baaedf2d7841eb9daaf2e135d3f0f92023-11-17T16:25:57ZengMDPI AGCancers2072-66942023-03-01157208710.3390/cancers15072087Anticardiolipin Antibodies in Patients with Cancer: A Case–Control StudyMd. Ashraful Islam Nipu0Shoumik Kundu1Sayeda Sadia Alam2Ashrafun Naher Dina3Md. Ashraful Hasan4Mohammad Khan5Md. Ibrahim Khalil6Tareq Hossan7Md Asiful Islam8Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshDepartment of Pharmacology & Therapeutics, Enam Medical College, Savar, Dhaka 1340, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshNew Age Health Science Research Center, Muradpur, Chattogram 4331, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka 1342, BangladeshWHO Collaborating Centre for Global Women’s Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UKAntiphospholipid antibodies are highly prevalent in autoimmune diseases and mainly associated with thromboembolic events, which is one of the major reasons for cancer-related mortality. Confirmed adult cancer patients were included (n = 40) with an equal number of age- and sex-matched healthy controls. The presence and concentration of anticardiolipin antibodies were investigated by the enzyme-linked immunosorbent assay using the venous blood samples. aCL antibodies were detected in 60.0% (n = 24) of the cancer patients compared to none in the healthy controls (<i>p</i> < 0.001). The serum concentration of aCL antibodies was significantly higher in cancer patients than controls (<i>p</i> < 0.001) and ranged from 89.0 U/mL to 133.0 U/mL among the aCL-positive patients. All the lung cancer patients (n = 6) were diagnosed with positive aCL, and a borderline significant association of aCL antibody positivity was observed in colon cancer patients (<i>p</i> = 0.051). About 72.7% of the advanced-stage cancer individuals and 81.8% of the cancer patients who underwent surgery were diagnosed with positive aCL antibodies. A significant association of aCL antibody positivity was observed with cancer patients comorbid with heart diseases (<i>p</i> = 0.005). The prevalence and serum levels of aCL antibodies were significantly higher in cancer patients compared to healthy controls. Cancer patients (i.e., lung, liver, and colon), at advanced-stage, comorbid with heart diseases, who underwent surgery, were more likely to be diagnosed with aCL antibodies.https://www.mdpi.com/2072-6694/15/7/2087cancerneoplasmsanticardiolipin antibodyantiphospholipid antibodiesautoimmunity |
| spellingShingle | Md. Ashraful Islam Nipu Shoumik Kundu Sayeda Sadia Alam Ashrafun Naher Dina Md. Ashraful Hasan Mohammad Khan Md. Ibrahim Khalil Tareq Hossan Md Asiful Islam Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study Cancers cancer neoplasms anticardiolipin antibody antiphospholipid antibodies autoimmunity |
| title | Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study |
| title_full | Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study |
| title_fullStr | Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study |
| title_full_unstemmed | Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study |
| title_short | Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study |
| title_sort | anticardiolipin antibodies in patients with cancer a case control study |
| topic | cancer neoplasms anticardiolipin antibody antiphospholipid antibodies autoimmunity |
| url | https://www.mdpi.com/2072-6694/15/7/2087 |
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