Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion
Concussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome, and chronic traumatic encephalopathy. At present, standard clinical imaging fails to reliably detect traumatic axonal injury associated with concussion and post-concu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00518/full |
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| author | Jacob M. Mallott Eva M. Palacios Jun Maruta Jun Maruta Jamshid Ghajar Jamshid Ghajar Pratik Mukherjee Pratik Mukherjee |
| author_facet | Jacob M. Mallott Eva M. Palacios Jun Maruta Jun Maruta Jamshid Ghajar Jamshid Ghajar Pratik Mukherjee Pratik Mukherjee |
| author_sort | Jacob M. Mallott |
| collection | DOAJ |
| description | Concussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome, and chronic traumatic encephalopathy. At present, standard clinical imaging fails to reliably detect traumatic axonal injury associated with concussion and post-concussive symptoms. Diffusion tensor imaging (DTI) is an MR imaging technique that is sensitive to changes in white matter microstructure. Prior studies using DTI did not jointly investigate white matter microstructure in athletes, a population at high risk for concussive and subconcussive head traumas, with those in typical emergency room (ER) patients. In this study, we determine DTI scalar metrics in both ER patients and scholastic athletes who suffered concussions and compared them to those in age-matched healthy controls. In the early subacute post-concussion period, athletes demonstrated an elevated rate of regional decreases in axial diffusivity (AD) compared to controls. These regional decreases of AD were especially pronounced in the cerebellar peduncles, and were more frequent in athletes compared to the ER patient sample. The group differences may indicate differences in the mechanisms of the concussive impacts as well as possible compound effects of cumulative subconcussive impacts in athletes. The prevalence of white matter abnormality in cerebellar tracts lends credence to the hypothesis that post-concussive symptoms are caused by shearing of axons within an attention network mediated by the cerebellum, and warrant further study of the correlation between cerebellar DTI findings and clinical, neurocognitive, oculomotor, and vestibular outcomes in mTBI patients. |
| first_indexed | 2024-04-13T07:47:54Z |
| format | Article |
| id | doaj.art-55bc96830bfc4417b2b8da7966344abc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T07:47:54Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-55bc96830bfc4417b2b8da7966344abc2022-12-22T02:55:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-05-011010.3389/fneur.2019.00518452604Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After ConcussionJacob M. Mallott0Eva M. Palacios1Jun Maruta2Jun Maruta3Jamshid Ghajar4Jamshid Ghajar5Pratik Mukherjee6Pratik Mukherjee7Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartments of Neurology and Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBrain Trauma Foundation, New York, NY, United StatesBrain Trauma Foundation, New York, NY, United StatesDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United StatesConcussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome, and chronic traumatic encephalopathy. At present, standard clinical imaging fails to reliably detect traumatic axonal injury associated with concussion and post-concussive symptoms. Diffusion tensor imaging (DTI) is an MR imaging technique that is sensitive to changes in white matter microstructure. Prior studies using DTI did not jointly investigate white matter microstructure in athletes, a population at high risk for concussive and subconcussive head traumas, with those in typical emergency room (ER) patients. In this study, we determine DTI scalar metrics in both ER patients and scholastic athletes who suffered concussions and compared them to those in age-matched healthy controls. In the early subacute post-concussion period, athletes demonstrated an elevated rate of regional decreases in axial diffusivity (AD) compared to controls. These regional decreases of AD were especially pronounced in the cerebellar peduncles, and were more frequent in athletes compared to the ER patient sample. The group differences may indicate differences in the mechanisms of the concussive impacts as well as possible compound effects of cumulative subconcussive impacts in athletes. The prevalence of white matter abnormality in cerebellar tracts lends credence to the hypothesis that post-concussive symptoms are caused by shearing of axons within an attention network mediated by the cerebellum, and warrant further study of the correlation between cerebellar DTI findings and clinical, neurocognitive, oculomotor, and vestibular outcomes in mTBI patients.https://www.frontiersin.org/article/10.3389/fneur.2019.00518/fullmagnetic resonancediffusion weighted imagingacquired brain injuryfractional anisotropytract-based spatial statistics |
| spellingShingle | Jacob M. Mallott Eva M. Palacios Jun Maruta Jun Maruta Jamshid Ghajar Jamshid Ghajar Pratik Mukherjee Pratik Mukherjee Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion Frontiers in Neurology magnetic resonance diffusion weighted imaging acquired brain injury fractional anisotropy tract-based spatial statistics |
| title | Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion |
| title_full | Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion |
| title_fullStr | Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion |
| title_full_unstemmed | Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion |
| title_short | Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion |
| title_sort | disrupted white matter microstructure of the cerebellar peduncles in scholastic athletes after concussion |
| topic | magnetic resonance diffusion weighted imaging acquired brain injury fractional anisotropy tract-based spatial statistics |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00518/full |
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