SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS
In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 w...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2015-01-01
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| Series: | Biology of Sport |
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| Online Access: | http://www.termedia.pl/SWIMMING-EXERCISE-STIMULATES-NEURO-GENESIS-IN-THE-SUBVENTRICULAR-ZONE-VIA-INCREASE-IN-SYNAPSIN-I-AND-NERVE-GROWTH-FACTOR-LEVELS,78,24335,1,1.html |
| _version_ | 1819292784857710592 |
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| author | Chae C-H S-L Jung S-H An B-Y Park T-W Kim S-W Wang J-H Kim H-C Lee H-T Kim |
| author_facet | Chae C-H S-L Jung S-H An B-Y Park T-W Kim S-W Wang J-H Kim H-C Lee H-T Kim |
| author_sort | Chae C-H |
| collection | DOAJ |
| description | In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and
6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2’-deoxyuridine-5’-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6;
p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB. |
| first_indexed | 2024-12-24T04:00:02Z |
| format | Article |
| id | doaj.art-55bdd25da0bf4376ada7c3263227e573 |
| institution | Directory Open Access Journal |
| issn | 0860-021X 2083-1862 |
| language | English |
| last_indexed | 2024-12-24T04:00:02Z |
| publishDate | 2015-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Biology of Sport |
| spelling | doaj.art-55bdd25da0bf4376ada7c3263227e5732022-12-21T17:16:20ZengTermedia Publishing HouseBiology of Sport0860-021X2083-18622015-01-0131430931410.5604/20831862.113213024335SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELSChae C-HS-L JungS-H AnB-Y ParkT-W KimS-W WangJ-H KimH-C LeeH-T KimIn this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and 6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2’-deoxyuridine-5’-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6; p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB.http://www.termedia.pl/SWIMMING-EXERCISE-STIMULATES-NEURO-GENESIS-IN-THE-SUBVENTRICULAR-ZONE-VIA-INCREASE-IN-SYNAPSIN-I-AND-NERVE-GROWTH-FACTOR-LEVELS,78,24335,1,1.htmlphysical training progenitor cells olfactory bulb neurotrophic factors brain ratssurvival |
| spellingShingle | Chae C-H S-L Jung S-H An B-Y Park T-W Kim S-W Wang J-H Kim H-C Lee H-T Kim SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS Biology of Sport physical training progenitor cells olfactory bulb neurotrophic factors brain ratssurvival |
| title | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
| title_full | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
| title_fullStr | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
| title_full_unstemmed | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
| title_short | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
| title_sort | swimming exercise stimulates neuro genesis in the subventricular zone via increase in synapsin i and nerve growth factor levels |
| topic | physical training progenitor cells olfactory bulb neurotrophic factors brain ratssurvival |
| url | http://www.termedia.pl/SWIMMING-EXERCISE-STIMULATES-NEURO-GENESIS-IN-THE-SUBVENTRICULAR-ZONE-VIA-INCREASE-IN-SYNAPSIN-I-AND-NERVE-GROWTH-FACTOR-LEVELS,78,24335,1,1.html |
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