Angiopoietin-2 in ischemic cardiac patients
Background: Coronary artery disease (CAD) is the most common cause of death globally according to WHO. Its known that ischemia and cardiac dysfunction promotes the angiogenesis and new vessel formation to compensate for the decreased blood supply through the diseased arteries.Angiopoietin-2(Ang-2) a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2023-07-01
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| Series: | SVU - International Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://svuijm.journals.ekb.eg/article_155114.html |
| _version_ | 1827894467005251584 |
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| author | Ahmed Magdy Abdelazim* Mohammed Abdelrazek Elsenbsy Mohammed H. Hassan Mohammed AK |
| author_facet | Ahmed Magdy Abdelazim* Mohammed Abdelrazek Elsenbsy Mohammed H. Hassan Mohammed AK |
| author_sort | Ahmed Magdy Abdelazim* |
| collection | DOAJ |
| description | Background: Coronary artery disease (CAD) is the most common cause of death globally according to WHO. Its known that ischemia and cardiac dysfunction promotes the angiogenesis and new vessel formation to compensate for the decreased blood supply through the diseased arteries.Angiopoietin-2(Ang-2) along with several other growth factors are responsible for the process of new vessel formation. Many patients have some degree of renal insufficiency post PCI mainly due to contrast media and are associated with rise in the serum Ang-2 level. Ang-2 is found to be decreased post PCI with the restoration of the normal blood flow. Many clinical trials relate the Ang-2 with the severity of CAD and renal function.
Objectives: Highlight the serum levels of Ang-2 pre and post PCI and its validity to be used to diagnose and predict severity of CAD.
Methods: We have searched literatures in PubMed, google scholar, Egyptian bank of knowledge and science direct.
Conclusion: In this review we emphasize that Ang-2 is found to be an important marker for diagnosis and prognosis of CAD and is closely related to renal functions in ischemic cardiac patients candidate for PCI. |
| first_indexed | 2024-03-12T22:07:57Z |
| format | Article |
| id | doaj.art-55be35318981407e8a4d041a7c77f3a0 |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-03-12T22:07:57Z |
| publishDate | 2023-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-55be35318981407e8a4d041a7c77f3a02023-07-24T09:33:13ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022023-07-0162 482488https://doi.org/10.21608/svuijm.2021.66008.1111Angiopoietin-2 in ischemic cardiac patientsAhmed Magdy Abdelazim*0Mohammed Abdelrazek Elsenbsy 1Mohammed H. Hassan 2Mohammed AK3Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, 83523 Egypt.Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, 83523 Egypt.; Internal Medicine Department ,Arabian Gulf University(AGU),Bahrain.Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, South Valley University, Qena, EgyptCardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South Valley University, Qena, 83523 Egypt.Background: Coronary artery disease (CAD) is the most common cause of death globally according to WHO. Its known that ischemia and cardiac dysfunction promotes the angiogenesis and new vessel formation to compensate for the decreased blood supply through the diseased arteries.Angiopoietin-2(Ang-2) along with several other growth factors are responsible for the process of new vessel formation. Many patients have some degree of renal insufficiency post PCI mainly due to contrast media and are associated with rise in the serum Ang-2 level. Ang-2 is found to be decreased post PCI with the restoration of the normal blood flow. Many clinical trials relate the Ang-2 with the severity of CAD and renal function. Objectives: Highlight the serum levels of Ang-2 pre and post PCI and its validity to be used to diagnose and predict severity of CAD. Methods: We have searched literatures in PubMed, google scholar, Egyptian bank of knowledge and science direct. Conclusion: In this review we emphasize that Ang-2 is found to be an important marker for diagnosis and prognosis of CAD and is closely related to renal functions in ischemic cardiac patients candidate for PCI.https://svuijm.journals.ekb.eg/article_155114.htmlpercutaneous coronary intervention (pci)contrast induced nephropathy (cin)angiopoietin-2(ang-2) |
| spellingShingle | Ahmed Magdy Abdelazim* Mohammed Abdelrazek Elsenbsy Mohammed H. Hassan Mohammed AK Angiopoietin-2 in ischemic cardiac patients SVU - International Journal of Medical Sciences percutaneous coronary intervention (pci) contrast induced nephropathy (cin) angiopoietin-2(ang-2) |
| title | Angiopoietin-2 in ischemic cardiac patients |
| title_full | Angiopoietin-2 in ischemic cardiac patients |
| title_fullStr | Angiopoietin-2 in ischemic cardiac patients |
| title_full_unstemmed | Angiopoietin-2 in ischemic cardiac patients |
| title_short | Angiopoietin-2 in ischemic cardiac patients |
| title_sort | angiopoietin 2 in ischemic cardiac patients |
| topic | percutaneous coronary intervention (pci) contrast induced nephropathy (cin) angiopoietin-2(ang-2) |
| url | https://svuijm.journals.ekb.eg/article_155114.html |
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