Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke. The study objective was to quantify dose-dep...

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Bibliographic Details
Main Authors: Susan M. Shea, Kimberly A. Thomas, Rassam M. G. Rassam, Emily P. Mihalko, Christina Daniel, Bruce A. Sullenger, Philip C. Spinella, Shahid M. Nimjee
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
microfluidics
ischemic stroke
aptamers
nucleotide
von Willebrand Factor
platelets
Online Access:https://www.mdpi.com/1424-8247/15/12/1450

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