Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.959502/full |
| _version_ | 1798046377176989696 |
|---|---|
| author | Bo Min Chu-xu Wang Juan Liu Li Gong Cheng-xiang Wang Xiao-hua Zuo |
| author_facet | Bo Min Chu-xu Wang Juan Liu Li Gong Cheng-xiang Wang Xiao-hua Zuo |
| author_sort | Bo Min |
| collection | DOAJ |
| description | Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety of symptoms and is frequently associated with other abnormalities. This report describes an 81-year-old woman who presented with an irritant cough. Chest computed tomography (CT) and three-dimensional (3D) reconstruction revealed an irregular mass with a diameter of 5 cm in right lower lobe adjacent to the hilum. CT also indicated a rightward mediastinal shift and the complete absence of ipsilateral upper lobar tissue with bronchus ending in a terminal cecum, resulting in a diagnosis of pulmonary aplasia. The patient accepted lobectomy and lymph node dissection without complication, histopathologic examination combined HE staining with immunohistochemistry identified the tumor as adenocarcinoma. Three months after surgery, the patient was free of respiratory symptoms without chest pain. This report highlights the necessity of comprehensive evaluation for lung malignancy concurrent with CPD and the importance of identifying the diagnosis of pulmonary dysplasia. |
| first_indexed | 2024-04-11T23:36:42Z |
| format | Article |
| id | doaj.art-55bead3e6ce4421695aef0d2c018766d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T23:36:42Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-55bead3e6ce4421695aef0d2c018766d2022-12-22T03:56:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.959502959502Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case reportBo Min0Chu-xu Wang1Juan Liu2Li Gong3Cheng-xiang Wang4Xiao-hua Zuo5Department of Thoracic Surgery, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaDepartment of Thoracic Surgery, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaDepartment of Anesthesiology, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaDepartment of Thoracic Surgery, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaDepartment of Thoracic Surgery, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaDepartment of Pain Management, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, ChinaLung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety of symptoms and is frequently associated with other abnormalities. This report describes an 81-year-old woman who presented with an irritant cough. Chest computed tomography (CT) and three-dimensional (3D) reconstruction revealed an irregular mass with a diameter of 5 cm in right lower lobe adjacent to the hilum. CT also indicated a rightward mediastinal shift and the complete absence of ipsilateral upper lobar tissue with bronchus ending in a terminal cecum, resulting in a diagnosis of pulmonary aplasia. The patient accepted lobectomy and lymph node dissection without complication, histopathologic examination combined HE staining with immunohistochemistry identified the tumor as adenocarcinoma. Three months after surgery, the patient was free of respiratory symptoms without chest pain. This report highlights the necessity of comprehensive evaluation for lung malignancy concurrent with CPD and the importance of identifying the diagnosis of pulmonary dysplasia.https://www.frontiersin.org/articles/10.3389/fonc.2022.959502/fullpulmonary aplasialung adenocarcinomaCPDlung abnormalities3D CT reconstruction |
| spellingShingle | Bo Min Chu-xu Wang Juan Liu Li Gong Cheng-xiang Wang Xiao-hua Zuo Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report Frontiers in Oncology pulmonary aplasia lung adenocarcinoma CPD lung abnormalities 3D CT reconstruction |
| title | Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report |
| title_full | Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report |
| title_fullStr | Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report |
| title_full_unstemmed | Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report |
| title_short | Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report |
| title_sort | lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe a case report |
| topic | pulmonary aplasia lung adenocarcinoma CPD lung abnormalities 3D CT reconstruction |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.959502/full |
| work_keys_str_mv | AT bomin lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport AT chuxuwang lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport AT juanliu lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport AT ligong lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport AT chengxiangwang lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport AT xiaohuazuo lungadenocarcinomaconcurrentwithcongenitalpulmonaryaplasiaoftherightupperlobeacasereport |