Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus.
Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weani...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5796690?pdf=render |
| _version_ | 1819065270831939584 |
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| author | Amanda E Hernan J Matthew Mahoney Willie Curry Greg Richard Marcella M Lucas Andrew Massey Gregory L Holmes Rod C Scott |
| author_facet | Amanda E Hernan J Matthew Mahoney Willie Curry Greg Richard Marcella M Lucas Andrew Massey Gregory L Holmes Rod C Scott |
| author_sort | Amanda E Hernan |
| collection | DOAJ |
| description | Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weaning environmental enrichment (EE). To establish how EE impacts network-level mechanisms of spatial cognition, hippocampal in vivo single unit recordings were performed in freely moving animals in an open arena. We took a generalized linear modeling approach to extract fine spike timing (FST) characteristics and related these to place cell fidelity used as a surrogate of spatial cognition. We find that MAM disrupts FST and place-modulated rate coding in hippocampal CA1 and that EE improves many FST parameters towards normal. Moreover, FST parameters predict spatial coherence of neurons, suggesting that mechanisms determining altered FST are responsible for impaired cognition in MCDs. This suggests that FST parameters could represent a therapeutic target to improve cognition even in the context of a brain that develops with a structural abnormality. |
| first_indexed | 2024-12-21T15:43:48Z |
| format | Article |
| id | doaj.art-55c1030974b0490484126c9939f64070 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:43:48Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-55c1030974b0490484126c9939f640702022-12-21T18:58:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019148810.1371/journal.pone.0191488Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus.Amanda E HernanJ Matthew MahoneyWillie CurryGreg RichardMarcella M LucasAndrew MasseyGregory L HolmesRod C ScottNeurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weaning environmental enrichment (EE). To establish how EE impacts network-level mechanisms of spatial cognition, hippocampal in vivo single unit recordings were performed in freely moving animals in an open arena. We took a generalized linear modeling approach to extract fine spike timing (FST) characteristics and related these to place cell fidelity used as a surrogate of spatial cognition. We find that MAM disrupts FST and place-modulated rate coding in hippocampal CA1 and that EE improves many FST parameters towards normal. Moreover, FST parameters predict spatial coherence of neurons, suggesting that mechanisms determining altered FST are responsible for impaired cognition in MCDs. This suggests that FST parameters could represent a therapeutic target to improve cognition even in the context of a brain that develops with a structural abnormality.http://europepmc.org/articles/PMC5796690?pdf=render |
| spellingShingle | Amanda E Hernan J Matthew Mahoney Willie Curry Greg Richard Marcella M Lucas Andrew Massey Gregory L Holmes Rod C Scott Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. PLoS ONE |
| title | Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. |
| title_full | Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. |
| title_fullStr | Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. |
| title_full_unstemmed | Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. |
| title_short | Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. |
| title_sort | environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus |
| url | http://europepmc.org/articles/PMC5796690?pdf=render |
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