EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications
Abstract Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46883-6 |
| _version_ | 1797559614666964992 |
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| author | Tiphaine Raia-Barjat Céline Chauleur Constance Collet Florence Rancon Pascale Hoffmann Morgane Desseux Nicolas Lemaitre Mohamed Benharouga Antoine Giraud Nadia Alfaidy |
| author_facet | Tiphaine Raia-Barjat Céline Chauleur Constance Collet Florence Rancon Pascale Hoffmann Morgane Desseux Nicolas Lemaitre Mohamed Benharouga Antoine Giraud Nadia Alfaidy |
| author_sort | Tiphaine Raia-Barjat |
| collection | DOAJ |
| description | Abstract Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women. |
| first_indexed | 2024-03-10T17:47:48Z |
| format | Article |
| id | doaj.art-55c505145c884852b2d78f6960bf73eb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:47:48Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-55c505145c884852b2d78f6960bf73eb2023-11-20T09:27:35ZengNature PortfolioScientific Reports2045-23222023-11-011311610.1038/s41598-023-46883-6EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complicationsTiphaine Raia-Barjat0Céline Chauleur1Constance Collet2Florence Rancon3Pascale Hoffmann4Morgane Desseux5Nicolas Lemaitre6Mohamed Benharouga7Antoine Giraud8Nadia Alfaidy9Department of Gynecology and Obstetrics, Hôpital Nord, University Hospital, Centre Hospitalier Universitaire de Saint-ÉtienneDepartment of Gynecology and Obstetrics, Hôpital Nord, University Hospital, Centre Hospitalier Universitaire de Saint-ÉtienneInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéINSERM U1059 SAINBIOSE, Université Jean MonnetInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéINSERM U1059 SAINBIOSE, Université Jean MonnetInstitut National de La Santé et de la Recherche Médicale (INSERM), U1292, MAB2 Team, Laboratoire de BioSantéAbstract Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women.https://doi.org/10.1038/s41598-023-46883-6 |
| spellingShingle | Tiphaine Raia-Barjat Céline Chauleur Constance Collet Florence Rancon Pascale Hoffmann Morgane Desseux Nicolas Lemaitre Mohamed Benharouga Antoine Giraud Nadia Alfaidy EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications Scientific Reports |
| title | EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications |
| title_full | EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications |
| title_fullStr | EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications |
| title_full_unstemmed | EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications |
| title_short | EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications |
| title_sort | eg vegf maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta mediated complications |
| url | https://doi.org/10.1038/s41598-023-46883-6 |
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