Functionally and Metabolically Divergent Melanoma-Associated Macrophages Originate from Common Bone-Marrow Precursors

Functionally and Metabolically Divergent Melanoma-Associated Macrophages Originate from Common Bone-Marrow Precursors

Tumor-associated macrophages (TAMs) can be widely heterogeneous, based on their ontogeny and function, and driven by the tissue-specific niche. TAMs are highly abundant in the melanoma tumor microenvironment (TME), usually correlating with worse prognoses. However, the understanding of their diversi...

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Bibliographic Details
Main Authors: Gabriela A. Pizzurro, Kate Bridges, Xiaodong Jiang, Aurobind Vidyarthi, Kathryn Miller-Jensen, Oscar R. Colegio
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
tumor-associated macrophages
melanoma
tumor microenvironment
macrophage ontogeny
immunosuppression
tissue-resident macrophages
Online Access:https://www.mdpi.com/2072-6694/15/13/3330

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