Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy
Diastolic dysfunction is an important determinant for prognosis and survival in several paediatric heart diseases. We aimed to explore its possible impact on outcome in children with dilated cardiomyopathy. From 2006 to 2016, children less than 18 years old with dilated cardiomyopathy were retrospec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/10/1500 |
| _version_ | 1797474228738457600 |
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| author | Sabrina Bressieux-Degueldre Matthew Fenton Troy Dominguez Michael Burch |
| author_facet | Sabrina Bressieux-Degueldre Matthew Fenton Troy Dominguez Michael Burch |
| author_sort | Sabrina Bressieux-Degueldre |
| collection | DOAJ |
| description | Diastolic dysfunction is an important determinant for prognosis and survival in several paediatric heart diseases. We aimed to explore its possible impact on outcome in children with dilated cardiomyopathy. From 2006 to 2016, children less than 18 years old with dilated cardiomyopathy were retrospectively enrolled. Echocardiographic diastolic function parameters and child outcomes were analysed. Of 43 children aged 0.2 to 16.1 years old referred with dilated cardiomyopathy, 8 patients required cardiac transplant or mechanical assist devices (18%), 24 had persistently abnormal left ventricular function and/or dilatation (56%) and 11 patients recovered (26%). There was no significant difference in mitral velocities on Tissue Doppler Imaging, mitral valve inflow velocities, isovolumic relaxation time, left atrial area z-score and mitral lateral E/e’ ratios between patients with recovery and patients with disease progression or persistently abnormal ventricular function and/or dilation. This is the first study on childhood dilated cardiomyopathy to address individual echocardiographic diastolic function parameters and their association to recovery. In this study, echocardiographic parameters for diastolic function did not predict recovery. |
| first_indexed | 2024-03-09T20:27:09Z |
| format | Article |
| id | doaj.art-55c981390b6b433ea5c4cf89075f1894 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:27:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-55c981390b6b433ea5c4cf89075f18942023-11-23T23:31:58ZengMDPI AGChildren2227-90672022-09-01910150010.3390/children9101500Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated CardiomyopathySabrina Bressieux-Degueldre0Matthew Fenton1Troy Dominguez2Michael Burch3Paediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UKPaediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UKCardiac Intensive Care Unit, Great Ormond Street Hospital for Children, London WC1N 3JH, UKPaediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UKDiastolic dysfunction is an important determinant for prognosis and survival in several paediatric heart diseases. We aimed to explore its possible impact on outcome in children with dilated cardiomyopathy. From 2006 to 2016, children less than 18 years old with dilated cardiomyopathy were retrospectively enrolled. Echocardiographic diastolic function parameters and child outcomes were analysed. Of 43 children aged 0.2 to 16.1 years old referred with dilated cardiomyopathy, 8 patients required cardiac transplant or mechanical assist devices (18%), 24 had persistently abnormal left ventricular function and/or dilatation (56%) and 11 patients recovered (26%). There was no significant difference in mitral velocities on Tissue Doppler Imaging, mitral valve inflow velocities, isovolumic relaxation time, left atrial area z-score and mitral lateral E/e’ ratios between patients with recovery and patients with disease progression or persistently abnormal ventricular function and/or dilation. This is the first study on childhood dilated cardiomyopathy to address individual echocardiographic diastolic function parameters and their association to recovery. In this study, echocardiographic parameters for diastolic function did not predict recovery.https://www.mdpi.com/2227-9067/9/10/1500diastolic functiondilated cardiomyopathychildrenechocardiography |
| spellingShingle | Sabrina Bressieux-Degueldre Matthew Fenton Troy Dominguez Michael Burch Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy Children diastolic function dilated cardiomyopathy children echocardiography |
| title | Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy |
| title_full | Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy |
| title_fullStr | Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy |
| title_full_unstemmed | Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy |
| title_short | Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy |
| title_sort | exploring the possible impact of echocardiographic diastolic function parameters on outcome in paediatric dilated cardiomyopathy |
| topic | diastolic function dilated cardiomyopathy children echocardiography |
| url | https://www.mdpi.com/2227-9067/9/10/1500 |
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