Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema
Intravitreal bevacizumab (IVB), often injected during cataract surgery, is currently the main treatment for diabetic macular edema. This retrospective study aimed to compare the effectiveness of IVB injections alone and during cataract surgery in patients with diabetic macular edema. We examined 43...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/12/4060 |
| _version_ | 1797594139568635904 |
|---|---|
| author | Jeeyoung Kwak You Hyun Lee Kyung Tae Kang Yu Cheol Kim |
| author_facet | Jeeyoung Kwak You Hyun Lee Kyung Tae Kang Yu Cheol Kim |
| author_sort | Jeeyoung Kwak |
| collection | DOAJ |
| description | Intravitreal bevacizumab (IVB), often injected during cataract surgery, is currently the main treatment for diabetic macular edema. This retrospective study aimed to compare the effectiveness of IVB injections alone and during cataract surgery in patients with diabetic macular edema. We examined 43 eyes in 40 patients who underwent cataract surgery with simultaneous IVB injections 3–12 months after IVB injections alone. Best-corrected visual acuity and central subfield macular thickness (CMT) were measured 1-month post-injection. The CMTs of the same eyes with IVB-only first and combined-treatment procedures later were 384 ± 149 vs. 315 ± 109 μm pretreatment (<i>p</i> = 0.0002), and after 1 month, they were 319 ± 102 vs. 419 ± 183 μm (<i>p</i> < 0.0001). In the IVB-only procedure, 56.1% of eyes had CMT < 300 μm 1 month after the injection compared to 32.5% after the combined treatment. Therefore, on average, when IVB was administered during cataract surgery, CMT increased, whereas after IVB injection alone, it effectively decreased. More prospective trials with large sample sizes are needed to evaluate the effectiveness of IVB injection performed simultaneously with cataract surgery. |
| first_indexed | 2024-03-11T02:18:17Z |
| format | Article |
| id | doaj.art-55ca8ab42d504b48bd3f33cd8b442d7d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T02:18:17Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-55ca8ab42d504b48bd3f33cd8b442d7d2023-11-18T11:00:25ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011212406010.3390/jcm12124060Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular EdemaJeeyoung Kwak0You Hyun Lee1Kyung Tae Kang2Yu Cheol Kim3Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of KoreaDepartment of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of KoreaDepartment of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of KoreaDepartment of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of KoreaIntravitreal bevacizumab (IVB), often injected during cataract surgery, is currently the main treatment for diabetic macular edema. This retrospective study aimed to compare the effectiveness of IVB injections alone and during cataract surgery in patients with diabetic macular edema. We examined 43 eyes in 40 patients who underwent cataract surgery with simultaneous IVB injections 3–12 months after IVB injections alone. Best-corrected visual acuity and central subfield macular thickness (CMT) were measured 1-month post-injection. The CMTs of the same eyes with IVB-only first and combined-treatment procedures later were 384 ± 149 vs. 315 ± 109 μm pretreatment (<i>p</i> = 0.0002), and after 1 month, they were 319 ± 102 vs. 419 ± 183 μm (<i>p</i> < 0.0001). In the IVB-only procedure, 56.1% of eyes had CMT < 300 μm 1 month after the injection compared to 32.5% after the combined treatment. Therefore, on average, when IVB was administered during cataract surgery, CMT increased, whereas after IVB injection alone, it effectively decreased. More prospective trials with large sample sizes are needed to evaluate the effectiveness of IVB injection performed simultaneously with cataract surgery.https://www.mdpi.com/2077-0383/12/12/4060bevacizumabcataract extractiondiabetic retinopathymacular edemaIrvine–Gass syndrome |
| spellingShingle | Jeeyoung Kwak You Hyun Lee Kyung Tae Kang Yu Cheol Kim Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema Journal of Clinical Medicine bevacizumab cataract extraction diabetic retinopathy macular edema Irvine–Gass syndrome |
| title | Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema |
| title_full | Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema |
| title_fullStr | Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema |
| title_full_unstemmed | Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema |
| title_short | Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema |
| title_sort | comparison of the effectiveness of intravitreal bevacizumab injections with and without simultaneous cataract surgery in diabetic patients with macular edema |
| topic | bevacizumab cataract extraction diabetic retinopathy macular edema Irvine–Gass syndrome |
| url | https://www.mdpi.com/2077-0383/12/12/4060 |
| work_keys_str_mv | AT jeeyoungkwak comparisonoftheeffectivenessofintravitrealbevacizumabinjectionswithandwithoutsimultaneouscataractsurgeryindiabeticpatientswithmacularedema AT youhyunlee comparisonoftheeffectivenessofintravitrealbevacizumabinjectionswithandwithoutsimultaneouscataractsurgeryindiabeticpatientswithmacularedema AT kyungtaekang comparisonoftheeffectivenessofintravitrealbevacizumabinjectionswithandwithoutsimultaneouscataractsurgeryindiabeticpatientswithmacularedema AT yucheolkim comparisonoftheeffectivenessofintravitrealbevacizumabinjectionswithandwithoutsimultaneouscataractsurgeryindiabeticpatientswithmacularedema |