Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers.
New neurons are continuously added in the dentate gyrus and the olfactory bulb of mammalian brain. While numerous environmental factors controlling survival of newborn neurons have been extensively studied, regulation by social interactions is less documented. We addressed this question by investiga...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00053/full |
| _version_ | 1818427911748714496 |
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| author | Maïna eBRUS Maryse eMeurisse Matthieu eKeller Frédéric eLevy |
| author_facet | Maïna eBRUS Maryse eMeurisse Matthieu eKeller Frédéric eLevy |
| author_sort | Maïna eBRUS |
| collection | DOAJ |
| description | New neurons are continuously added in the dentate gyrus and the olfactory bulb of mammalian brain. While numerous environmental factors controlling survival of newborn neurons have been extensively studied, regulation by social interactions is less documented. We addressed this question by investigating the influence of parturition and interactions with the young on neurogenesis in sheep mothers. Using Bromodeoxyuridine, a marker of cell division, in combination with markers of neuronal maturation, the percentage of neuroblasts and new mature neurons in the olfactory bulb and the dentate gyrus was compared between groups of parturient ewes which could interact or not with their lamb, and virgins. In addition, a morphological analysis was performed by measuring the dendritic arbor of neuroblasts in both structures. We showed that the post-partum period was associated with a decrease in olfactory and hippocampal adult neurogenesis. In the olfactory bulb, the suppressive effect on neuroblasts was dependent on interactions with the young whereas in the dentate gyrus the decrease in new mature neurons was associated with parturition. In addition, dendritic length and number of nodes of neuroblasts were significantly enhanced by interactions with the lamb in the olfactory bulb but not in the dentate gyrus. Because interactions with the young involved learning of the olfactory signature of the lamb, we hypothesize that this learning is associated with a down-regulation in olfactory neurogenesis and an enhancement of olfactory neuroblast maturation. Our assumption is that fewer new neurons decrease cell competition in the olfactory bulb and enhance maturation of those new neurons selected to participate in the learning of the young odor. |
| first_indexed | 2024-12-14T14:53:15Z |
| format | Article |
| id | doaj.art-55cb26a0292a4b8fac5d58ffcd631236 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-14T14:53:15Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-55cb26a0292a4b8fac5d58ffcd6312362022-12-21T22:57:04ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-02-01810.3389/fnbeh.2014.0005376887Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers.Maïna eBRUS0Maryse eMeurisse1Matthieu eKeller2Frédéric eLevy3INRAINRAINRAINRANew neurons are continuously added in the dentate gyrus and the olfactory bulb of mammalian brain. While numerous environmental factors controlling survival of newborn neurons have been extensively studied, regulation by social interactions is less documented. We addressed this question by investigating the influence of parturition and interactions with the young on neurogenesis in sheep mothers. Using Bromodeoxyuridine, a marker of cell division, in combination with markers of neuronal maturation, the percentage of neuroblasts and new mature neurons in the olfactory bulb and the dentate gyrus was compared between groups of parturient ewes which could interact or not with their lamb, and virgins. In addition, a morphological analysis was performed by measuring the dendritic arbor of neuroblasts in both structures. We showed that the post-partum period was associated with a decrease in olfactory and hippocampal adult neurogenesis. In the olfactory bulb, the suppressive effect on neuroblasts was dependent on interactions with the young whereas in the dentate gyrus the decrease in new mature neurons was associated with parturition. In addition, dendritic length and number of nodes of neuroblasts were significantly enhanced by interactions with the lamb in the olfactory bulb but not in the dentate gyrus. Because interactions with the young involved learning of the olfactory signature of the lamb, we hypothesize that this learning is associated with a down-regulation in olfactory neurogenesis and an enhancement of olfactory neuroblast maturation. Our assumption is that fewer new neurons decrease cell competition in the olfactory bulb and enhance maturation of those new neurons selected to participate in the learning of the young odor.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00053/fullHippocampusMaternal BehaviorOlfactory Bulbbrain plasticityOlfactory learning |
| spellingShingle | Maïna eBRUS Maryse eMeurisse Matthieu eKeller Frédéric eLevy Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. Frontiers in Behavioral Neuroscience Hippocampus Maternal Behavior Olfactory Bulb brain plasticity Olfactory learning |
| title | Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. |
| title_full | Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. |
| title_fullStr | Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. |
| title_full_unstemmed | Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. |
| title_short | Interactions with the young down-regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers. |
| title_sort | interactions with the young down regulate adult olfactory neurogenesis and enhance the maturation of olfactory neuroblasts in sheep mothers |
| topic | Hippocampus Maternal Behavior Olfactory Bulb brain plasticity Olfactory learning |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00053/full |
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