Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

ABSTRACT Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent tissue virus reservoirs. While these myeloid cells are poorly infected by cell-free viruses because of the...

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Bibliographic Details
Main Authors: Maorong Xie, Héloïse Leroy, Rémi Mascarau, Marie Woottum, Maeva Dupont, Camille Ciccone, Alain Schmitt, Brigitte Raynaud-Messina, Christel Vérollet, Jérôme Bouchet, Lucie Bracq, Serge Benichou
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
HIV-1
SAMHD1
cell fusion
myeloid cells
virus spreading
Online Access:https://journals.asm.org/doi/10.1128/mBio.02457-19

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