Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule
Abstract Epidemiological and clinical observations have shown that potassium ingestion is inversely correlated with arterial hypertension prevalence and cardiovascular mortality. The higher the dietary potassium, the lower the blood pressure and mortality. This phenomenon is explained, at least in p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-12-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202114273 |
| _version_ | 1827015200403881984 |
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| author | María Castañeda‐Bueno David H Ellison Gerardo Gamba |
| author_facet | María Castañeda‐Bueno David H Ellison Gerardo Gamba |
| author_sort | María Castañeda‐Bueno |
| collection | DOAJ |
| description | Abstract Epidemiological and clinical observations have shown that potassium ingestion is inversely correlated with arterial hypertension prevalence and cardiovascular mortality. The higher the dietary potassium, the lower the blood pressure and mortality. This phenomenon is explained, at least in part, by the interaction between salt reabsorption in the distal convoluted tubule (DCT) and potassium secretion in the connecting tubule/collecting duct of the mammalian nephron: In order to achieve adequate K+ secretion levels under certain conditions, salt reabsorption in the DCT must be reduced. Because salt handling by the kidney constitutes the basis for the long‐term regulation of blood pressure, losing salt prevents hypertension. Here, we discuss how the study of inherited diseases in which salt reabsorption in the DCT is affected has revealed the molecular players, including membrane transporters and channels, kinases, and ubiquitin ligases that form the potassium sensing mechanism of the DCT and the processes through which the consequent adjustments in salt reabsorption are achieved. |
| first_indexed | 2024-03-07T18:51:16Z |
| format | Article |
| id | doaj.art-55cec973cc7d4bd4a357b7f2065bc904 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2025-02-18T14:19:43Z |
| publishDate | 2021-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-55cec973cc7d4bd4a357b7f2065bc9042024-10-28T08:52:07ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-12-0114211510.15252/emmm.202114273Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubuleMaría Castañeda‐Bueno0David H Ellison1Gerardo Gamba2Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science UniversityDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránAbstract Epidemiological and clinical observations have shown that potassium ingestion is inversely correlated with arterial hypertension prevalence and cardiovascular mortality. The higher the dietary potassium, the lower the blood pressure and mortality. This phenomenon is explained, at least in part, by the interaction between salt reabsorption in the distal convoluted tubule (DCT) and potassium secretion in the connecting tubule/collecting duct of the mammalian nephron: In order to achieve adequate K+ secretion levels under certain conditions, salt reabsorption in the DCT must be reduced. Because salt handling by the kidney constitutes the basis for the long‐term regulation of blood pressure, losing salt prevents hypertension. Here, we discuss how the study of inherited diseases in which salt reabsorption in the DCT is affected has revealed the molecular players, including membrane transporters and channels, kinases, and ubiquitin ligases that form the potassium sensing mechanism of the DCT and the processes through which the consequent adjustments in salt reabsorption are achieved.https://doi.org/10.15252/emmm.202114273epithelial transportfamilial hyperkalemic hypertensiongitelman syndromepotassiumSESAME/EAST syndrome |
| spellingShingle | María Castañeda‐Bueno David H Ellison Gerardo Gamba Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule EMBO Molecular Medicine epithelial transport familial hyperkalemic hypertension gitelman syndrome potassium SESAME/EAST syndrome |
| title | Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| title_full | Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| title_fullStr | Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| title_full_unstemmed | Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| title_short | Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| title_sort | molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule |
| topic | epithelial transport familial hyperkalemic hypertension gitelman syndrome potassium SESAME/EAST syndrome |
| url | https://doi.org/10.15252/emmm.202114273 |
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