Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering
Identifying venous voxels in fMRI datasets is important to increase the specificity of fMRI analyses to microvasculature in the vicinity of the neural processes triggering the BOLD response. This is, however, difficult to achieve in particular in typical studies where magnitude images of BOLD EPI ar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00472/full |
| _version_ | 1811265978326056960 |
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| author | Klaudius eKalcher Klaudius eKalcher Roland N Boubela Roland N Boubela Wolfgang eHuf Wolfgang eHuf Christian eNasel Ewald eMoser Ewald eMoser Ewald eMoser |
| author_facet | Klaudius eKalcher Klaudius eKalcher Roland N Boubela Roland N Boubela Wolfgang eHuf Wolfgang eHuf Christian eNasel Ewald eMoser Ewald eMoser Ewald eMoser |
| author_sort | Klaudius eKalcher |
| collection | DOAJ |
| description | Identifying venous voxels in fMRI datasets is important to increase the specificity of fMRI analyses to microvasculature in the vicinity of the neural processes triggering the BOLD response. This is, however, difficult to achieve in particular in typical studies where magnitude images of BOLD EPI are the only data available. In this study, voxelwise functional connectivity graphs were computed on minimally preprocessed low TR (333 ms) multiband resting-state fMRI data, using both high positive and negative correlations to define edges between nodes (voxels). A high correlation threshold for binarization ensures that most edges in the resulting sparse graph reflect the high coherence of signals in medium to large veins. Graph clustering based on the optimization of modularity was then employed to identify clusters of coherent voxels in this graph, and all clusters of 50 or more voxels were then interpreted as corresponding to medium to large veins. Indeed, a comparison with SWI reveals that 75.6 ± 5.9% of voxels within these large clusters overlap with veins visible in the SWI image or lie outside the brain parenchyma. Some of the remainingdifferences between the two modalities can be explained by imperfect alignment or geometric distortions between the two images. Overall, the graph clustering based method for identifying venous voxels has a high specificity as well as the additional advantages of being computed in the same voxel grid as the fMRI dataset itself and not needingany additional data beyond what is usually acquired (and exported) in standard fMRI experiments. |
| first_indexed | 2024-04-12T20:33:44Z |
| format | Article |
| id | doaj.art-55d09ae3e8af4262bd37dc12d26a142d |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T20:33:44Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-55d09ae3e8af4262bd37dc12d26a142d2022-12-22T03:17:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-12-01910.3389/fnins.2015.00472165511Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph ClusteringKlaudius eKalcher0Klaudius eKalcher1Roland N Boubela2Roland N Boubela3Wolfgang eHuf4Wolfgang eHuf5Christian eNasel6Ewald eMoser7Ewald eMoser8Ewald eMoser9Medical University of ViennaMedical University of ViennaMedical University of ViennaMedical University of ViennaMedical University of ViennaMedical University of ViennaTulln Hospital, Karl Landsteiner University of Health SciencesMedical University of ViennaMedical University of ViennaUniversity of Pennsylvania Medical CenterIdentifying venous voxels in fMRI datasets is important to increase the specificity of fMRI analyses to microvasculature in the vicinity of the neural processes triggering the BOLD response. This is, however, difficult to achieve in particular in typical studies where magnitude images of BOLD EPI are the only data available. In this study, voxelwise functional connectivity graphs were computed on minimally preprocessed low TR (333 ms) multiband resting-state fMRI data, using both high positive and negative correlations to define edges between nodes (voxels). A high correlation threshold for binarization ensures that most edges in the resulting sparse graph reflect the high coherence of signals in medium to large veins. Graph clustering based on the optimization of modularity was then employed to identify clusters of coherent voxels in this graph, and all clusters of 50 or more voxels were then interpreted as corresponding to medium to large veins. Indeed, a comparison with SWI reveals that 75.6 ± 5.9% of voxels within these large clusters overlap with veins visible in the SWI image or lie outside the brain parenchyma. Some of the remainingdifferences between the two modalities can be explained by imperfect alignment or geometric distortions between the two images. Overall, the graph clustering based method for identifying venous voxels has a high specificity as well as the additional advantages of being computed in the same voxel grid as the fMRI dataset itself and not needingany additional data beyond what is usually acquired (and exported) in standard fMRI experiments.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00472/fullBrainVeinsfMRIBOLDgraph analysisphysiological signals |
| spellingShingle | Klaudius eKalcher Klaudius eKalcher Roland N Boubela Roland N Boubela Wolfgang eHuf Wolfgang eHuf Christian eNasel Ewald eMoser Ewald eMoser Ewald eMoser Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering Frontiers in Neuroscience Brain Veins fMRI BOLD graph analysis physiological signals |
| title | Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering |
| title_full | Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering |
| title_fullStr | Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering |
| title_full_unstemmed | Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering |
| title_short | Identification of Voxels Confounded by Venous Signals Using Resting-State fMRI Functional Connectivity Graph Clustering |
| title_sort | identification of voxels confounded by venous signals using resting state fmri functional connectivity graph clustering |
| topic | Brain Veins fMRI BOLD graph analysis physiological signals |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00472/full |
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