Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.
In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro us...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5614539?pdf=render |
| _version_ | 1828810897180590080 |
|---|---|
| author | Jun-Pil Jang Hye Jin Jung Jang Mi Han Narae Jung Yonghyo Kim Ho Jeong Kwon Sung-Kyun Ko Nak-Kyun Soung Jae-Hyuk Jang Jong Seog Ahn |
| author_facet | Jun-Pil Jang Hye Jin Jung Jang Mi Han Narae Jung Yonghyo Kim Ho Jeong Kwon Sung-Kyun Ko Nak-Kyun Soung Jae-Hyuk Jang Jong Seog Ahn |
| author_sort | Jun-Pil Jang |
| collection | DOAJ |
| description | In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed vascular endothelial growth factor (VEGF)-induced migration, invasion, proliferation and tube formation of HUVECs as well as neovascularization of the chorioallantoic membrane in developing chick embryos. We also identified an association between the antiangiogenic activity of 1 and 2 and the downregulation of both the phosphorylation of VEGF receptor 2 and the expression of hypoxia inducible factor-1α at the protein level. Taken together, these results further suggest that compounds 1 and 2 will be promising angiogenesis inhibitors. |
| first_indexed | 2024-12-12T09:18:57Z |
| format | Article |
| id | doaj.art-55d501d32b1a4413acaf5da062107b19 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T09:18:57Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-55d501d32b1a4413acaf5da062107b192022-12-22T00:29:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018433910.1371/journal.pone.0184339Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.Jun-Pil JangHye Jin JungJang Mi HanNarae JungYonghyo KimHo Jeong KwonSung-Kyun KoNak-Kyun SoungJae-Hyuk JangJong Seog AhnIn the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed vascular endothelial growth factor (VEGF)-induced migration, invasion, proliferation and tube formation of HUVECs as well as neovascularization of the chorioallantoic membrane in developing chick embryos. We also identified an association between the antiangiogenic activity of 1 and 2 and the downregulation of both the phosphorylation of VEGF receptor 2 and the expression of hypoxia inducible factor-1α at the protein level. Taken together, these results further suggest that compounds 1 and 2 will be promising angiogenesis inhibitors.http://europepmc.org/articles/PMC5614539?pdf=render |
| spellingShingle | Jun-Pil Jang Hye Jin Jung Jang Mi Han Narae Jung Yonghyo Kim Ho Jeong Kwon Sung-Kyun Ko Nak-Kyun Soung Jae-Hyuk Jang Jong Seog Ahn Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. PLoS ONE |
| title | Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. |
| title_full | Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. |
| title_fullStr | Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. |
| title_full_unstemmed | Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. |
| title_short | Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities. |
| title_sort | two cyclic hexapeptides from penicillium sp fn070315 with antiangiogenic activities |
| url | http://europepmc.org/articles/PMC5614539?pdf=render |
| work_keys_str_mv | AT junpiljang twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT hyejinjung twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT jangmihan twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT naraejung twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT yonghyokim twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT hojeongkwon twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT sungkyunko twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT nakkyunsoung twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT jaehyukjang twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities AT jongseogahn twocyclichexapeptidesfrompenicilliumspfn070315withantiangiogenicactivities |