Recent Progress on Hyaluronan-Based Products for Wound Healing Applications
Hyaluronic acid (HA) based nanocomposites are considered excellent for improving wound healing. HA is biocompatible, biodegradable, non-toxic, biologically active, has hemostatic ability, and resists bacterial adhesion. HA-based nanocomposites promote wound healing in four different sequential phase...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2235 |
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| author | Kuncham Sudhakar Seong min Ji Madhusudhana Rao Kummara Sung Soo Han |
| author_facet | Kuncham Sudhakar Seong min Ji Madhusudhana Rao Kummara Sung Soo Han |
| author_sort | Kuncham Sudhakar |
| collection | DOAJ |
| description | Hyaluronic acid (HA) based nanocomposites are considered excellent for improving wound healing. HA is biocompatible, biodegradable, non-toxic, biologically active, has hemostatic ability, and resists bacterial adhesion. HA-based nanocomposites promote wound healing in four different sequential phases hemostasis, inflammation, proliferation, and maturation. The unique biological characteristics of HA enable it to serve as a drug, an antibacterial agent, and a growth factor, which combine to accelerate the healing process. In this review, we focus on the use of HA-based nanocomposites for wound healing applications and we describe the importance of HA for the wound healing process in each sequential phase, such as hemostasis, inflammation, proliferation, and maturation. Metal nanoparticles (MNPs) or metal oxide nanoparticles (MO-NPs) loaded with HA nanocomposite are used for wound healing applications. Insights into important antibacterial mechanisms are described in HA nanocomposites. Furthermore, we explain antibiotics loaded with HA nanocomposite and its combination with the MNPs/MO-NPs used for wound healing applications. In addition, HA derivatives are discussed and used in combination with the other polymers of the composite for the wound healing process, as is the role of the polymer in wound healing applications. Finally, HA-based nanocomposites used for clinical trials in animal models are presented for wound healing applications. |
| first_indexed | 2024-03-09T19:34:33Z |
| format | Article |
| id | doaj.art-55d5072590cf42aea015e0d1e982fdf0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:34:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-55d5072590cf42aea015e0d1e982fdf02023-11-24T01:58:45ZengMDPI AGPharmaceutics1999-49232022-10-011410223510.3390/pharmaceutics14102235Recent Progress on Hyaluronan-Based Products for Wound Healing ApplicationsKuncham Sudhakar0Seong min Ji1Madhusudhana Rao Kummara2Sung Soo Han3School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, KoreaSchool of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, KoreaSchool of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, KoreaSchool of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, KoreaHyaluronic acid (HA) based nanocomposites are considered excellent for improving wound healing. HA is biocompatible, biodegradable, non-toxic, biologically active, has hemostatic ability, and resists bacterial adhesion. HA-based nanocomposites promote wound healing in four different sequential phases hemostasis, inflammation, proliferation, and maturation. The unique biological characteristics of HA enable it to serve as a drug, an antibacterial agent, and a growth factor, which combine to accelerate the healing process. In this review, we focus on the use of HA-based nanocomposites for wound healing applications and we describe the importance of HA for the wound healing process in each sequential phase, such as hemostasis, inflammation, proliferation, and maturation. Metal nanoparticles (MNPs) or metal oxide nanoparticles (MO-NPs) loaded with HA nanocomposite are used for wound healing applications. Insights into important antibacterial mechanisms are described in HA nanocomposites. Furthermore, we explain antibiotics loaded with HA nanocomposite and its combination with the MNPs/MO-NPs used for wound healing applications. In addition, HA derivatives are discussed and used in combination with the other polymers of the composite for the wound healing process, as is the role of the polymer in wound healing applications. Finally, HA-based nanocomposites used for clinical trials in animal models are presented for wound healing applications.https://www.mdpi.com/1999-4923/14/10/2235hyaluronic acidmetal/metal oxide nanoparticlesantibiotic drugsantibacterial activitywound healing |
| spellingShingle | Kuncham Sudhakar Seong min Ji Madhusudhana Rao Kummara Sung Soo Han Recent Progress on Hyaluronan-Based Products for Wound Healing Applications Pharmaceutics hyaluronic acid metal/metal oxide nanoparticles antibiotic drugs antibacterial activity wound healing |
| title | Recent Progress on Hyaluronan-Based Products for Wound Healing Applications |
| title_full | Recent Progress on Hyaluronan-Based Products for Wound Healing Applications |
| title_fullStr | Recent Progress on Hyaluronan-Based Products for Wound Healing Applications |
| title_full_unstemmed | Recent Progress on Hyaluronan-Based Products for Wound Healing Applications |
| title_short | Recent Progress on Hyaluronan-Based Products for Wound Healing Applications |
| title_sort | recent progress on hyaluronan based products for wound healing applications |
| topic | hyaluronic acid metal/metal oxide nanoparticles antibiotic drugs antibacterial activity wound healing |
| url | https://www.mdpi.com/1999-4923/14/10/2235 |
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