Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice
Arsenite is a well-documented neurotoxic metalloid that widely distributes in the natural environment. However, it remains largely unclear how arsenite affects neurological function. Therefore, in this study, the healthy adult male mice were exposed to 0.5 mg/L and 5 mg/L arsenite through drinking w...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322012106 |
| _version_ | 1797961274542260224 |
|---|---|
| author | Zhaohong Lu Fanghong Wang Yinyin Xia Shuqun Cheng Jun Zhang Xia Qin Xin Tian Bin Wang Jingfu Qiu Zhen Zou Xuejun Jiang Chengzhi Chen |
| author_facet | Zhaohong Lu Fanghong Wang Yinyin Xia Shuqun Cheng Jun Zhang Xia Qin Xin Tian Bin Wang Jingfu Qiu Zhen Zou Xuejun Jiang Chengzhi Chen |
| author_sort | Zhaohong Lu |
| collection | DOAJ |
| description | Arsenite is a well-documented neurotoxic metalloid that widely distributes in the natural environment. However, it remains largely unclear how arsenite affects neurological function. Therefore, in this study, the healthy adult male mice were exposed to 0.5 mg/L and 5 mg/L arsenite through drinking water for 30 and 90 days, respectively. Our results showed that there was no significant alteration in the intestine and brain for 30 days exposure, but exposure to arsenite for 90 days significantly induced a reduction of locomotor activity and anxiety-like behavior, caused pathological damage and inflammatory responses in the brain and intestine. We also found that arsenite remarkably disrupted intestinal barrier integrity, decreased the levels of lysozyme and digestive enzymes. Intriguingly, chronic exposure to arsenite significantly changed the levels of gut-brain peptides. Taken together, this study provides meaningful insights that gut-brain communication may involve in the neurobehavioral impairments of arsenite. |
| first_indexed | 2024-04-11T00:56:28Z |
| format | Article |
| id | doaj.art-55d529d326df4b699a616a9d73ada008 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-11T00:56:28Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-55d529d326df4b699a616a9d73ada0082023-01-05T04:30:24ZengElsevierEcotoxicology and Environmental Safety0147-65132023-01-01249114370Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male miceZhaohong Lu0Fanghong Wang1Yinyin Xia2Shuqun Cheng3Jun Zhang4Xia Qin5Xin Tian6Bin Wang7Jingfu Qiu8Zhen Zou9Xuejun Jiang10Chengzhi Chen11Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaDepartment of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Research Center for Environment and Human Health, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Corresponding author at: Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, People’s Republic of China.Research Center for Environment and Human Health, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Center of Experimental Teaching for Public Health, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Correspondence to: No. 1, Yixueyuan Road, Yuzhong District, Chongqing 400016, People’s Republic of China.Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Research Center for Environment and Human Health, Chongqing Medical University, Chongqing 400016, People’s Republic of China; Corresponding author at: Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People’s Republic of China.Arsenite is a well-documented neurotoxic metalloid that widely distributes in the natural environment. However, it remains largely unclear how arsenite affects neurological function. Therefore, in this study, the healthy adult male mice were exposed to 0.5 mg/L and 5 mg/L arsenite through drinking water for 30 and 90 days, respectively. Our results showed that there was no significant alteration in the intestine and brain for 30 days exposure, but exposure to arsenite for 90 days significantly induced a reduction of locomotor activity and anxiety-like behavior, caused pathological damage and inflammatory responses in the brain and intestine. We also found that arsenite remarkably disrupted intestinal barrier integrity, decreased the levels of lysozyme and digestive enzymes. Intriguingly, chronic exposure to arsenite significantly changed the levels of gut-brain peptides. Taken together, this study provides meaningful insights that gut-brain communication may involve in the neurobehavioral impairments of arsenite.http://www.sciencedirect.com/science/article/pii/S0147651322012106ArseniteIntestinal impairmentNeurobehavioral impairmentGut-brain axis |
| spellingShingle | Zhaohong Lu Fanghong Wang Yinyin Xia Shuqun Cheng Jun Zhang Xia Qin Xin Tian Bin Wang Jingfu Qiu Zhen Zou Xuejun Jiang Chengzhi Chen Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice Ecotoxicology and Environmental Safety Arsenite Intestinal impairment Neurobehavioral impairment Gut-brain axis |
| title | Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice |
| title_full | Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice |
| title_fullStr | Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice |
| title_full_unstemmed | Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice |
| title_short | Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice |
| title_sort | involvement of gut brain communication in arsenite induced neurobehavioral impairments in adult male mice |
| topic | Arsenite Intestinal impairment Neurobehavioral impairment Gut-brain axis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322012106 |
| work_keys_str_mv | AT zhaohonglu involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT fanghongwang involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT yinyinxia involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT shuquncheng involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT junzhang involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT xiaqin involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT xintian involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT binwang involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT jingfuqiu involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT zhenzou involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT xuejunjiang involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice AT chengzhichen involvementofgutbraincommunicationinarseniteinducedneurobehavioralimpairmentsinadultmalemice |