Combination Treatment of TRPV4 Agonist with Cisplatin Promotes Vessel Normalization in an Animal Model of Oral Squamous Cell Carcinoma

Combination Treatment of TRPV4 Agonist with Cisplatin Promotes Vessel Normalization in an Animal Model of Oral Squamous Cell Carcinoma

<i>Background and Objectives</i>: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in the world. Transient receptor potential vanilloid 4 (TRPV4) channel has been shown to be involved in angiogenesis in multiple types of tumors. However, not much is known about TRP...

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Bibliographic Details
Main Authors: Farhana Yahya, Marina Mohd Bakri, Mohammad Zakir Hossain, Syarifah Nur Syed Abdul Rahman, Aied Mohammed Alabsi, Anand Ramanathan
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Medicina
Subjects:
oral squamous cell carcinoma (OSCC)
transient receptor potential vanilloid 4 (TRPV4)
4-nitroquinoline 1-oxide (4NQO)
angiogenesis
vascular normalization
Online Access:https://www.mdpi.com/1648-9144/58/9/1229

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