Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights
This review initiates by outlining the clinical relevance of IA, underlining the pressing need to comprehend its foundational elements. We delve into the assorted risk factors tied to IA, spotlighting both environmental and genetic influences. Additionally, we illuminate distinct genetic syndromes l...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/10/1454 |
| _version_ | 1797574501142102016 |
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| author | Corneliu Toader Lucian Eva Bogdan-Gabriel Bratu Razvan-Adrian Covache-Busuioc Horia Petre Costin David-Ioan Dumitrascu Luca-Andrei Glavan Antonio Daniel Corlatescu Alexandru Vlad Ciurea |
| author_facet | Corneliu Toader Lucian Eva Bogdan-Gabriel Bratu Razvan-Adrian Covache-Busuioc Horia Petre Costin David-Ioan Dumitrascu Luca-Andrei Glavan Antonio Daniel Corlatescu Alexandru Vlad Ciurea |
| author_sort | Corneliu Toader |
| collection | DOAJ |
| description | This review initiates by outlining the clinical relevance of IA, underlining the pressing need to comprehend its foundational elements. We delve into the assorted risk factors tied to IA, spotlighting both environmental and genetic influences. Additionally, we illuminate distinct genetic syndromes linked to a pronounced prevalence of intracranial aneurysms, underscoring the pivotal nature of genetics in this ailment’s susceptibility. A detailed scrutiny of genome-wide association studies allows us to identify key genomic changes and locations associated with IA risk. We further detail the molecular and physiopathological dynamics instrumental in IA’s evolution and escalation, with a focus on inflammation’s role in affecting the vascular landscape. Wrapping up, we offer a glimpse into upcoming research directions and the promising horizons of personalized therapeutic strategies in IA intervention, emphasizing the central role of genetic insights. This thorough review solidifies genetics’ cardinal role in IA, positioning it as a cornerstone resource for professionals in the realms of neurology and genomics. |
| first_indexed | 2024-03-10T21:23:26Z |
| format | Article |
| id | doaj.art-55d72f1585cb44e2986af44a4d5d8320 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:26Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-55d72f1585cb44e2986af44a4d5d83202023-11-19T15:53:10ZengMDPI AGBrain Sciences2076-34252023-10-011310145410.3390/brainsci13101454Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking InsightsCorneliu Toader0Lucian Eva1Bogdan-Gabriel Bratu2Razvan-Adrian Covache-Busuioc3Horia Petre Costin4David-Ioan Dumitrascu5Luca-Andrei Glavan6Antonio Daniel Corlatescu7Alexandru Vlad Ciurea8Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, Dunarea de Jos University, 800010 Galati, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaThis review initiates by outlining the clinical relevance of IA, underlining the pressing need to comprehend its foundational elements. We delve into the assorted risk factors tied to IA, spotlighting both environmental and genetic influences. Additionally, we illuminate distinct genetic syndromes linked to a pronounced prevalence of intracranial aneurysms, underscoring the pivotal nature of genetics in this ailment’s susceptibility. A detailed scrutiny of genome-wide association studies allows us to identify key genomic changes and locations associated with IA risk. We further detail the molecular and physiopathological dynamics instrumental in IA’s evolution and escalation, with a focus on inflammation’s role in affecting the vascular landscape. Wrapping up, we offer a glimpse into upcoming research directions and the promising horizons of personalized therapeutic strategies in IA intervention, emphasizing the central role of genetic insights. This thorough review solidifies genetics’ cardinal role in IA, positioning it as a cornerstone resource for professionals in the realms of neurology and genomics.https://www.mdpi.com/2076-3425/13/10/1454intracranial aneurysmgenetic syndromesgenome-wide association studiesmolecular mechanismsinflammatory statusgenomic modifications |
| spellingShingle | Corneliu Toader Lucian Eva Bogdan-Gabriel Bratu Razvan-Adrian Covache-Busuioc Horia Petre Costin David-Ioan Dumitrascu Luca-Andrei Glavan Antonio Daniel Corlatescu Alexandru Vlad Ciurea Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights Brain Sciences intracranial aneurysm genetic syndromes genome-wide association studies molecular mechanisms inflammatory status genomic modifications |
| title | Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights |
| title_full | Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights |
| title_fullStr | Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights |
| title_full_unstemmed | Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights |
| title_short | Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights |
| title_sort | intracranial aneurysms and genetics an extensive overview of genomic variations underlying molecular dynamics inflammatory indicators and forward looking insights |
| topic | intracranial aneurysm genetic syndromes genome-wide association studies molecular mechanisms inflammatory status genomic modifications |
| url | https://www.mdpi.com/2076-3425/13/10/1454 |
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