Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide

Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide

An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.

Bibliographic Details
Main Authors: Dongming Zhang, Bin Lv, Pan Gao, Xiaodong Jia, Yu Yuan
Format: Article
Language:English
Published: Beilstein-Institut 2022-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amination
copper
n-hydroxyphthalimides
radical reactions
triethyl phosphite
Online Access:https://doi.org/10.3762/bjoc.18.65

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