Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaquesResearch in context

Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaquesResearch in context

Summary: Background: Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women with low frequency or unplanned sexual activity or who prefer not to use daily or long-acting pre-exposure prophylaxis (PrEP). We performed dose ranging pharm...

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Bibliographic Details
Main Authors: Charles W. Dobard, M. Melissa Peet, Kenji Nishiura, Angela Holder, Chuong Dinh, James Mitchell, George Khalil, Yi Pan, Onkar N. Singh, Timothy J. McCormick, Vivek Agrahari, Pardeep Gupta, Sriramakamal Jonnalagadda, Walid Heneine, Meredith R. Clark, J. Gerardo García-Lerma, Gustavo F. Doncel
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Vaginal inserts
Tenofovir alafenamide
Elvitegravir
On-demand PrEP and PEP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005436

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http://www.sciencedirect.com/science/article/pii/S2352396422005436

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