Machilin D Promotes Apoptosis and Autophagy, and Inhibits Necroptosis in Human Oral Squamous Cell Carcinoma Cells

Machilin D Promotes Apoptosis and Autophagy, and Inhibits Necroptosis in Human Oral Squamous Cell Carcinoma Cells

Oral squamous cell carcinoma (OSCC) accounts for about 90% of all head and neck cancers, the prognosis is very poor, and there are no effective targeted therapies. Herein, we isolated Machilin D (Mach), a lignin, from the roots of <i>Saururus chinensis</i> (<i>S. chinensis</i>...

Full description

Bibliographic Details
Main Authors:	Hyung-Mun Yun, Yoon-Ju Kwon, Eonmi Kim, Hea-Jong Chung, Kyung-Ran Park
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	International Journal of Molecular Sciences
Subjects:	apoptosis autophagy Machilin D necroptosis OSCC
Online Access:	https://www.mdpi.com/1422-0067/24/5/4576

Similar Items

Xanol Promotes Apoptosis and Autophagy and Inhibits Necroptosis and Metastasis via the Inhibition of AKT Signaling in Human Oral Squamous Cell Carcinoma
by: Hyung-Mun Yun, et al.
Published: (2023-07-01)

Latifolin, a Natural Flavonoid, Isolated from the Heartwood of <i>Dalbergia odorifera</i> Induces Bioactivities through Apoptosis, Autophagy, and Necroptosis in Human Oral Squamous Cell Carcinoma
by: Hyung-Mun Yun, et al.
Published: (2022-11-01)

Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid
by: Tae-Wook Chung, et al.
Published: (2019-07-01)

Ilimaquinone Induces Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma Cells
by: Cheng-Wen Lin, et al.
Published: (2020-08-01)

Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line
by: Hui Sun, et al.
Published: (2016-04-01)

Activation of autophagy in photoreceptor necroptosis after experimental retinal detachment
by: Kai Dong, et al.
Published: (2014-10-01)

FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma
by: Bo Qiu, et al.
Published: (2023-05-01)

Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy
by: Lee Ying-Ray, et al.
Published: (2012-01-01)

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
by: Di Wang, et al.
Published: (2022-11-01)

Autophagy, apoptosis, necroptosis, pyroptosis and netosis in pathogenesis of immune-inflammatory rheumatic diseases
by: M. Z. Saidov
Published: (2022-07-01)

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
by: Shi C, et al.
Published: (2023-04-01)

Long non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis
by: Xiaolin Lu, et al.
Published: (2021-01-01)

Advances in the regulatory mechanisms of mTOR in necroptosis
by: Yawen Xie, et al.
Published: (2023-12-01)

Necroptosis as a Novel Facet of Mitotic Catastrophe
by: Aleksandra Yu. Egorshina, et al.
Published: (2022-03-01)

Autophagy and necroptosis in cisplatin-induced acute kidney injury: Recent advances regarding their role and therapeutic potential
by: Noha Alassaf, et al.
Published: (2023-01-01)

Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes
by: Yao Huang, et al.
Published: (2021-07-01)

CSFV restricts necroptosis to sustain infection by inducing autophagy/mitophagy-targeted degradation of RIPK3
by: Keke Wu, et al.
Published: (2024-01-01)

Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells
by: Li Liu, et al.
Published: (2019-07-01)

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis
by: Jian Yang, et al.
Published: (2022-01-01)

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
by: Junghyun Lim, et al.
Published: (2019-07-01)

Grand Challenges in Cell Death and Survival: Apoptosis vs. Necroptosis
by: Craig Michael Walsh
Published: (2014-02-01)

Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells
by: Parul Katiyar, et al.
Published: (2022-01-01)

PROLIFERATION AND APOPTOSIS IN RAT MODELS OF ORAL SQUAMOUS CELL CARCINOMA INDUCED BY CAPSAICIN EXTRACT NANOPARTICLE GEL
by: Pratiwi Nur Widyaningsih, et al.
Published: (2023-11-01)

Apoptosis y necroptosis en las enfermedades oftalmológicas
by: Raisa Ivis Beltrán Saínz, et al.

Trifloroside Induces Bioactive Effects on Differentiation, Adhesion, Migration, and Mineralization in Pre-Osteoblast MC3T3E-1 Cells
by: Hyung-Mun Yun, et al.
Published: (2022-12-01)

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis
by: Minggang Zhu, et al.
Published: (2023-11-01)

Necroptosis, tumor necrosis and tumorigenesis
by: Zheng-gang Liu, et al.
Published: (2019-12-01)

Role of Induced Programmed Cell Death in the Chemopreventive Potential of Apigenin
by: Jung Yoon Jang, et al.
Published: (2022-03-01)

The roles of FADD in extrinsic apoptosis and necroptosis
by: Eun-Woo Lee1,*, Jinho Seo1, Manhyung Jeong1, Sangsik Lee2 & Jaewhan Song1,*
Published: (2012-09-01)

Comparison of Necroptosis With Apoptosis for OVX-Induced Osteoporosis
by: Bin He, et al.
Published: (2021-12-01)

Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury through Dual Suppression of Apoptosis and Necroptosis
by: Jong Woo Kim, et al.
Published: (2019-08-01)

Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury
by: Bo Xu, et al.
Published: (2023-09-01)

Increased FOXM1 Expression by Cisplatin Inhibits Paclitaxel-Related Apoptosis in Cisplatin-Resistant Human Oral Squamous Cell Carcinoma (OSCC) Cell Lines
by: Hyeong Sim Choi, et al.
Published: (2020-11-01)

The Role of Necroptosis in Atherosclerotic Disease
by: Nicholas J. Leeper, MD
Published: (2016-10-01)

BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease
by: Arul M. Mani, et al.
Published: (2022-09-01)

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways
by: Yaqiu Wang, et al.
Published: (2021-01-01)

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma
by: Ke Huang, et al.
Published: (2023-09-01)

Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells
by: Jie Chen, et al.
Published: (2024-12-01)

Genetic variants in key necroptosis regulators predict prognosis of non‐small cell lung cancer after surgical resection
by: Jang Hyuck Lee, et al.
Published: (2023-09-01)

C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells
by: Wenyuan Zhu, et al.
Published: (2014-02-01)