Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area.
BACKGROUND: Transmission of malaria in West African urban areas is low and healthcare facilities are well organized. However, malaria mortality remains high. We conducted a survey in Dakar with the general objective to establish who died from severe malaria (SM) in urban areas (particularly looking...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2843705?pdf=render |
| _version_ | 1818153484958040064 |
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| author | Ndeye Sakha Bob Bernard Marcel Diop Francois Renaud Laurence Marrama Patrick Durand Adama Tall Boubacar Ka Marie Therese Ekala Christiane Bouchier Odile Mercereau-Puijalon Ronan Jambou |
| author_facet | Ndeye Sakha Bob Bernard Marcel Diop Francois Renaud Laurence Marrama Patrick Durand Adama Tall Boubacar Ka Marie Therese Ekala Christiane Bouchier Odile Mercereau-Puijalon Ronan Jambou |
| author_sort | Ndeye Sakha Bob |
| collection | DOAJ |
| description | BACKGROUND: Transmission of malaria in West African urban areas is low and healthcare facilities are well organized. However, malaria mortality remains high. We conducted a survey in Dakar with the general objective to establish who died from severe malaria (SM) in urban areas (particularly looking at the age-groups) and to compare parasite isolates associated with mild or severe malaria. METHODOLOGY/PRINCIPAL FINDINGS: The current study included mild- (MM) and severe malaria (SM) cases, treated in dispensaries (n = 2977) and hospitals (n = 104), We analysed Pfdhfr/Pfcrt-exon2 and nine microsatellite loci in 102 matched cases of SM and MM. Half of the malaria cases recorded at the dispensaries and 87% of SM cases referred to hospitals, occurred in adults, although adults only accounted for 26% of all dispensary consultations. This suggests that, in urban settings, whatever the reason for this adult over-representation, health-workers are forced to take care of increasing numbers of malaria cases among adults. Inappropriate self treatment and mutations in genes associated with drug resistance were found associated with SM in adults. SM was also associated with a specific pool of isolates highly polymorphic and different from those associated with MM. CONCLUSION: In this urban setting, adults currently represent one of the major groups of patients attending dispensaries for malaria treatment. For these patients, despite the low level of transmission, SM was associated with a specific and highly polymorphic pool of parasites which may have been selected by inappropriate treatment. |
| first_indexed | 2024-12-11T14:11:21Z |
| format | Article |
| id | doaj.art-55d8843f6ff64132a418fcf99cc9a42a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T14:11:21Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-55d8843f6ff64132a418fcf99cc9a42a2022-12-22T01:03:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0153e981710.1371/journal.pone.0009817Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area.Ndeye Sakha BobBernard Marcel DiopFrancois RenaudLaurence MarramaPatrick DurandAdama TallBoubacar KaMarie Therese EkalaChristiane BouchierOdile Mercereau-PuijalonRonan JambouBACKGROUND: Transmission of malaria in West African urban areas is low and healthcare facilities are well organized. However, malaria mortality remains high. We conducted a survey in Dakar with the general objective to establish who died from severe malaria (SM) in urban areas (particularly looking at the age-groups) and to compare parasite isolates associated with mild or severe malaria. METHODOLOGY/PRINCIPAL FINDINGS: The current study included mild- (MM) and severe malaria (SM) cases, treated in dispensaries (n = 2977) and hospitals (n = 104), We analysed Pfdhfr/Pfcrt-exon2 and nine microsatellite loci in 102 matched cases of SM and MM. Half of the malaria cases recorded at the dispensaries and 87% of SM cases referred to hospitals, occurred in adults, although adults only accounted for 26% of all dispensary consultations. This suggests that, in urban settings, whatever the reason for this adult over-representation, health-workers are forced to take care of increasing numbers of malaria cases among adults. Inappropriate self treatment and mutations in genes associated with drug resistance were found associated with SM in adults. SM was also associated with a specific pool of isolates highly polymorphic and different from those associated with MM. CONCLUSION: In this urban setting, adults currently represent one of the major groups of patients attending dispensaries for malaria treatment. For these patients, despite the low level of transmission, SM was associated with a specific and highly polymorphic pool of parasites which may have been selected by inappropriate treatment.http://europepmc.org/articles/PMC2843705?pdf=render |
| spellingShingle | Ndeye Sakha Bob Bernard Marcel Diop Francois Renaud Laurence Marrama Patrick Durand Adama Tall Boubacar Ka Marie Therese Ekala Christiane Bouchier Odile Mercereau-Puijalon Ronan Jambou Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. PLoS ONE |
| title | Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. |
| title_full | Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. |
| title_fullStr | Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. |
| title_full_unstemmed | Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. |
| title_short | Parasite polymorphism and severe malaria in Dakar (Senegal): a West African urban area. |
| title_sort | parasite polymorphism and severe malaria in dakar senegal a west african urban area |
| url | http://europepmc.org/articles/PMC2843705?pdf=render |
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