Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms
Skin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of hyperpigmentation and our evolving comprehension of its underlying mechanisms underscore t...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1296046/full |
| _version_ | 1797493096461631488 |
|---|---|
| author | Junying Qu Mengjun Yan Yimeng Fang Jing Zhao Ting Xu Fan Liu Kun Zhang Luqing He Libo Jin Da Sun |
| author_facet | Junying Qu Mengjun Yan Yimeng Fang Jing Zhao Ting Xu Fan Liu Kun Zhang Luqing He Libo Jin Da Sun |
| author_sort | Junying Qu |
| collection | DOAJ |
| description | Skin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of hyperpigmentation and our evolving comprehension of its underlying mechanisms underscore the need for robust animal models. Zebrafish, renowned for their transparent embryos and genetic parallels to humans, have been spotlighted as a pivotal model for skin pigmentation studies. This review offers a concise overview of zebrafish skin attributes, highlighting the shared melanin production pathways with humans. We systematically dissect the diverse strategies to craft zebrafish models of abnormal skin pigmentation, spanning physical, chemical, and genetic interventions, while critically appraising the merits and constraints of each approach. Additionally, we elucidate the metrics employed to gauge the efficacy of these models. Concluding, we cast a visionary gaze on prospective breakthroughs in the domain, aiming to steer forthcoming efforts in refined zebrafish models for skin pigmentation research. |
| first_indexed | 2024-03-10T01:15:06Z |
| format | Article |
| id | doaj.art-55d8d75414394ac3b24b79dd3f356d03 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-10T01:15:06Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-55d8d75414394ac3b24b79dd3f356d032023-11-23T14:10:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-11-011410.3389/fphys.2023.12960461296046Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanismsJunying Qu0Mengjun Yan1Yimeng Fang2Jing Zhao3Ting Xu4Fan Liu5Kun Zhang6Luqing He7Libo Jin8Da Sun9Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaZhuji People’s Hospital of Zhejiang Province, Zhuji, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaKey Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, ChinaDepartment of Science and Education, The Third People’s Hospital Health Care Group of Cixi, Ningbo, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, ChinaSkin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of hyperpigmentation and our evolving comprehension of its underlying mechanisms underscore the need for robust animal models. Zebrafish, renowned for their transparent embryos and genetic parallels to humans, have been spotlighted as a pivotal model for skin pigmentation studies. This review offers a concise overview of zebrafish skin attributes, highlighting the shared melanin production pathways with humans. We systematically dissect the diverse strategies to craft zebrafish models of abnormal skin pigmentation, spanning physical, chemical, and genetic interventions, while critically appraising the merits and constraints of each approach. Additionally, we elucidate the metrics employed to gauge the efficacy of these models. Concluding, we cast a visionary gaze on prospective breakthroughs in the domain, aiming to steer forthcoming efforts in refined zebrafish models for skin pigmentation research.https://www.frontiersin.org/articles/10.3389/fphys.2023.1296046/fullzebrafishmelaninpigmentation disordersskinmodels |
| spellingShingle | Junying Qu Mengjun Yan Yimeng Fang Jing Zhao Ting Xu Fan Liu Kun Zhang Luqing He Libo Jin Da Sun Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms Frontiers in Physiology zebrafish melanin pigmentation disorders skin models |
| title | Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| title_full | Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| title_fullStr | Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| title_full_unstemmed | Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| title_short | Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| title_sort | zebrafish in dermatology a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms |
| topic | zebrafish melanin pigmentation disorders skin models |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1296046/full |
| work_keys_str_mv | AT junyingqu zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT mengjunyan zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT yimengfang zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT jingzhao zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT tingxu zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT fanliu zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT kunzhang zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT luqinghe zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT libojin zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms AT dasun zebrafishindermatologyacomprehensivereviewoftheirroleininvestigatingabnormalskinpigmentationmechanisms |