Relationship between Antimicrobial Consumption and the Incidence of Antimicrobial Resistance in Escherichia coli and Klebsiella pneumoniae Isolates
Introduction: Gram negative organisms are one of the major causes of nosocomial diseases. Development of resistance to antibiotics by these organisms increases their risk in clinical treatment of patients. It also affects morbidity and mortality hence needs to be monitored and controlled. Aim:...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5537/11029_CE(RA1)_F(T)_PF1(NJAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Gram negative organisms are one of the major
causes of nosocomial diseases. Development of resistance to
antibiotics by these organisms increases their risk in clinical
treatment of patients. It also affects morbidity and mortality hence
needs to be monitored and controlled.
Aim: The aim of the present study was to analyse the correlation
between consumption of parenteral antibiotics and the rates of
antimicrobial resistance among the Escherichia coli and Klebsiella
pneumoniae isolates collected during Dec 2010 - Jun 2013 from
JIPMER hospital.
Materials and Methods: Consumption data of parenteral
antibiotics in J01 category of Anatomical Therapeutic Chemical
(ATC) in JIPMER was obtained and expressed in Defined Daily
Doses (DDD) per 1000 inhabitants. Valid consumption and
resistance data during the period Dec 2010 to Jun 2013 were
obtained at 6 month intervals and were correlated to draw a
relationship between antimicrobial consumption and its impact on
drug resistance for Escherichia coli and Klebsiella pneumoniae.
Results: Escherichia coli isolates showed high resistance for
increased use of gentamycin and ciprofloxacin. Increase in
antibiotic consumption increases the resistance for Escherichia coli
except for amikacin. Among the Klebsiella isolates, meropenem
and gentamycin showed high correlations followed by ceftazidime,
amikacin, ceftriaxone and ciprofloxacin.
Conclusion: In summary, a statistically significant association
was noticed between consumption of the studied antimicrobials
and resistance of Escherichia coli isolates, except for amikacin
and ceftazidime. In the case of Klebsiella pneumoniae, there was
a statistically significant association between the resistance rates
and consumption of gentamycin, ceftazidime and meropenem.
Further, a linear relationship was noted between antimicrobial
consumption and resistant isolates of Escherichia coli and
Klebsiella pneumoniae, except for Escherichia coli resistance to
amikacin. |
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| ISSN: | 2249-782X 0973-709X |