Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is a valuable alternative to pharmacotherapy alone in an advanced Parkinson's disease (PD). Given the growing number of patients with STN-DBS, its impact on the comorbidities should be considered.Aim: The aim of this study was to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.563445/full |
| _version_ | 1818297740780634112 |
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| author | Joanna Samborska-Ćwik Stanisław Szlufik Andrzej Friedman Tomasz Mandat Andrzej Przybyszewski Dariusz Koziorowski |
| author_facet | Joanna Samborska-Ćwik Stanisław Szlufik Andrzej Friedman Tomasz Mandat Andrzej Przybyszewski Dariusz Koziorowski |
| author_sort | Joanna Samborska-Ćwik |
| collection | DOAJ |
| description | Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is a valuable alternative to pharmacotherapy alone in an advanced Parkinson's disease (PD). Given the growing number of patients with STN-DBS, its impact on the comorbidities should be considered.Aim: The aim of this study was to evaluate the influence of bilateral STN-DBS on the lipid profile in patients with PD.Methods: Three groups of parkinsonian patients were included: 20 treated pharmacologically–PHT group, 20 newly qualified for STN-DBS–DBS group, and 14 postoperative patients (median 30 months after surgery)–POP group. Plasma concentrations of the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and body weight were measured thrice in 9 ± 2 month intervals.Results: A significant increase in the LDL-C concentration is observed early after surgery in the DBS group (11.4 mg/dl, P < 0.01) followed by adverse changes in the HDL-C (−7.7 mg/dl, P = 0.01) and TG (14.1 mg/dl, P = 0.05) plasma levels. In the POP group, the average level of TC at the first visit was significantly higher (P < 0.01) than in the other groups and the TG level was higher than in the PHT group during the follow-up (P < 0.01). A strong positive correlation with body weight alteration after surgery was observed only for long-term changes in the TG levels.Conclusions: Our data indicate that STN-DBS may negatively affect the cardiometabolic profile of patients. Similarly to body weight gain, an increase in the LDL-C concentration occurred early after surgery while adverse changes in the HDL-C and TG plasma levels were more gradual. |
| first_indexed | 2024-12-13T04:24:14Z |
| format | Article |
| id | doaj.art-55db52a4ee284ee8a3f6eb9737cc48aa |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T04:24:14Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-55db52a4ee284ee8a3f6eb9737cc48aa2022-12-21T23:59:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-10-011110.3389/fneur.2020.563445563445Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's DiseaseJoanna Samborska-Ćwik0Stanisław Szlufik1Andrzej Friedman2Tomasz Mandat3Andrzej Przybyszewski4Dariusz Koziorowski5Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, PolandDepartment of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, PolandDepartment of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, PolandDepartment of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, PolandDepartment of Informatics, Polish-Japanese Academy of Information Technology, Warsaw, PolandDepartment of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, PolandBackground: Subthalamic nucleus deep brain stimulation (STN-DBS) is a valuable alternative to pharmacotherapy alone in an advanced Parkinson's disease (PD). Given the growing number of patients with STN-DBS, its impact on the comorbidities should be considered.Aim: The aim of this study was to evaluate the influence of bilateral STN-DBS on the lipid profile in patients with PD.Methods: Three groups of parkinsonian patients were included: 20 treated pharmacologically–PHT group, 20 newly qualified for STN-DBS–DBS group, and 14 postoperative patients (median 30 months after surgery)–POP group. Plasma concentrations of the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and body weight were measured thrice in 9 ± 2 month intervals.Results: A significant increase in the LDL-C concentration is observed early after surgery in the DBS group (11.4 mg/dl, P < 0.01) followed by adverse changes in the HDL-C (−7.7 mg/dl, P = 0.01) and TG (14.1 mg/dl, P = 0.05) plasma levels. In the POP group, the average level of TC at the first visit was significantly higher (P < 0.01) than in the other groups and the TG level was higher than in the PHT group during the follow-up (P < 0.01). A strong positive correlation with body weight alteration after surgery was observed only for long-term changes in the TG levels.Conclusions: Our data indicate that STN-DBS may negatively affect the cardiometabolic profile of patients. Similarly to body weight gain, an increase in the LDL-C concentration occurred early after surgery while adverse changes in the HDL-C and TG plasma levels were more gradual.https://www.frontiersin.org/article/10.3389/fneur.2020.563445/fulldeep brain simulationParkinson's diseaselipidscholesteroltriglyceridesbody weight |
| spellingShingle | Joanna Samborska-Ćwik Stanisław Szlufik Andrzej Friedman Tomasz Mandat Andrzej Przybyszewski Dariusz Koziorowski Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease Frontiers in Neurology deep brain simulation Parkinson's disease lipids cholesterol triglycerides body weight |
| title | Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease |
| title_full | Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease |
| title_fullStr | Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease |
| title_full_unstemmed | Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease |
| title_short | Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on the Lipid Profile in Patients With Parkinson's Disease |
| title_sort | influence of bilateral subthalamic nucleus deep brain stimulation on the lipid profile in patients with parkinson s disease |
| topic | deep brain simulation Parkinson's disease lipids cholesterol triglycerides body weight |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.563445/full |
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