Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism.

Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism.

Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins, TcdA and TcdB, which are responsible for the symptoms of C. difficile associated disease. The mechanism of toxin action includes an autoproc...

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Bibliographic Details
Main Authors: Nicole M Chumbler, Melissa A Farrow, Lynne A Lapierre, Jeffrey L Franklin, David B Haslam, James R Goldenring, D Borden Lacy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3516567?pdf=render

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