Papillary Thyroid Cancer Prognosis: An Evolving Field
Over the last few years, a great advance has been made in the comprehension of the molecular pathogenesis underlying thyroid cancer progression, particularly for the papillary thyroid cancer (PTC), which represents the most common thyroid malignancy. Putative cancer driver mutations have been identi...
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Format: | Article |
Language: | English |
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MDPI AG
2021-11-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/13/21/5567 |
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author | Salvatore Ulisse Enke Baldini Augusto Lauro Daniele Pironi Domenico Tripodi Eleonora Lori Iulia Catalina Ferent Maria Ida Amabile Antonio Catania Filippo Maria Di Matteo Flavio Forte Alberto Santoro Piergaspare Palumbo Vito D’Andrea Salvatore Sorrenti |
author_facet | Salvatore Ulisse Enke Baldini Augusto Lauro Daniele Pironi Domenico Tripodi Eleonora Lori Iulia Catalina Ferent Maria Ida Amabile Antonio Catania Filippo Maria Di Matteo Flavio Forte Alberto Santoro Piergaspare Palumbo Vito D’Andrea Salvatore Sorrenti |
author_sort | Salvatore Ulisse |
collection | DOAJ |
description | Over the last few years, a great advance has been made in the comprehension of the molecular pathogenesis underlying thyroid cancer progression, particularly for the papillary thyroid cancer (PTC), which represents the most common thyroid malignancy. Putative cancer driver mutations have been identified in more than 98% of PTC, and a new PTC classification into molecular subtypes has been proposed in order to resolve clinical uncertainties still present in the clinical management of patients. Additionally, the prognostic stratification systems have been profoundly modified over the last decade, with a view to refine patients’ staging and being able to choose a clinical approach tailored on single patient’s needs. Here, we will briefly discuss the recent changes in the clinical management of thyroid nodules, and review the current staging systems of thyroid cancer patients by analyzing promising clinicopathological features (i.e., gender, thyroid auto-immunity, multifocality, PTC histological variants, and vascular invasion) as well as new molecular markers (i.e., BRAF/TERT promoter mutations, miRNAs, and components of the plasminogen activating system) potentially capable of ameliorating the prognosis of PTC patients. |
first_indexed | 2024-03-10T06:04:33Z |
format | Article |
id | doaj.art-55dd12b4951f49a08a6be3eedaf75e4d |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T06:04:33Z |
publishDate | 2021-11-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-55dd12b4951f49a08a6be3eedaf75e4d2023-11-22T20:37:09ZengMDPI AGCancers2072-66942021-11-011321556710.3390/cancers13215567Papillary Thyroid Cancer Prognosis: An Evolving FieldSalvatore Ulisse0Enke Baldini1Augusto Lauro2Daniele Pironi3Domenico Tripodi4Eleonora Lori5Iulia Catalina Ferent6Maria Ida Amabile7Antonio Catania8Filippo Maria Di Matteo9Flavio Forte10Alberto Santoro11Piergaspare Palumbo12Vito D’Andrea13Salvatore Sorrenti14Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyUrology Department, M.G. Vannini Hospital, 00177 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyOver the last few years, a great advance has been made in the comprehension of the molecular pathogenesis underlying thyroid cancer progression, particularly for the papillary thyroid cancer (PTC), which represents the most common thyroid malignancy. Putative cancer driver mutations have been identified in more than 98% of PTC, and a new PTC classification into molecular subtypes has been proposed in order to resolve clinical uncertainties still present in the clinical management of patients. Additionally, the prognostic stratification systems have been profoundly modified over the last decade, with a view to refine patients’ staging and being able to choose a clinical approach tailored on single patient’s needs. Here, we will briefly discuss the recent changes in the clinical management of thyroid nodules, and review the current staging systems of thyroid cancer patients by analyzing promising clinicopathological features (i.e., gender, thyroid auto-immunity, multifocality, PTC histological variants, and vascular invasion) as well as new molecular markers (i.e., BRAF/TERT promoter mutations, miRNAs, and components of the plasminogen activating system) potentially capable of ameliorating the prognosis of PTC patients.https://www.mdpi.com/2072-6694/13/21/5567thyroid cancersmolecular pathogenesisprognosistherapyTNMtumor molecular profiling |
spellingShingle | Salvatore Ulisse Enke Baldini Augusto Lauro Daniele Pironi Domenico Tripodi Eleonora Lori Iulia Catalina Ferent Maria Ida Amabile Antonio Catania Filippo Maria Di Matteo Flavio Forte Alberto Santoro Piergaspare Palumbo Vito D’Andrea Salvatore Sorrenti Papillary Thyroid Cancer Prognosis: An Evolving Field Cancers thyroid cancers molecular pathogenesis prognosis therapy TNM tumor molecular profiling |
title | Papillary Thyroid Cancer Prognosis: An Evolving Field |
title_full | Papillary Thyroid Cancer Prognosis: An Evolving Field |
title_fullStr | Papillary Thyroid Cancer Prognosis: An Evolving Field |
title_full_unstemmed | Papillary Thyroid Cancer Prognosis: An Evolving Field |
title_short | Papillary Thyroid Cancer Prognosis: An Evolving Field |
title_sort | papillary thyroid cancer prognosis an evolving field |
topic | thyroid cancers molecular pathogenesis prognosis therapy TNM tumor molecular profiling |
url | https://www.mdpi.com/2072-6694/13/21/5567 |
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