Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients
Background: According to the cause, chronic urticaria is most frequently divided into autoimmune and idiopathic urticaria. Aim of the paper was to determine the frequency of autoimmune urticaria using autologous serum skin testing and a comparative analysis of chronic idiopathic and chronic autoimmu...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2021-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2021/2490-33292104239N.pdf |
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| author | Ninković-Baroš Đuka Gajanin Vesna Zrnić Bogdan Gajanin Živorad Katalina Gordana |
| author_facet | Ninković-Baroš Đuka Gajanin Vesna Zrnić Bogdan Gajanin Živorad Katalina Gordana |
| author_sort | Ninković-Baroš Đuka |
| collection | DOAJ |
| description | Background: According to the cause, chronic urticaria is most frequently divided into autoimmune and idiopathic urticaria. Aim of the paper was to determine the frequency of autoimmune urticaria using autologous serum skin testing and a comparative analysis of chronic idiopathic and chronic autoimmune urticaria by disease course, severity and most common comorbidities. Methods: Analysis covered 64 adult patients of both sexes with chronic urticaria, divided into two groups according to their positivity in autologous serum skin testing (group I with positive test and group II with negative test). General haematological and biochemical parameters, antithyroid antibodies, hepatitis serum markers, Helicobacter pylori and Borrelia burgdorferi antibodies were performed for patients in both groups. First group patients were treated by autologous blood therapy (autohaemotherapy). The analytical statistical tool SPSS (Statistical Product and Service Solutions) version 20 for descriptive statistics and statistical methods was used. The significance level used was p = 0.05. Results: The frequency of positive autologous serum test in total population of patients with chronic urticaria was 43.8 %. The average duration of urticaria was 20 months in both groups. Statistically significant difference was found in weekly scores between the studied groups (p = 0.032) in favour of chronic autoimmune urticaria with a positive autologous serum test. Subjects with chronic autoimmune urticaria had a significantly higher association with autoimmune thyroid diseases. Conclusions: Direct relation was established between the use of autologous blood therapy in patients with autoimmune chronic urticaria and improvement of the clinical picture. |
| first_indexed | 2024-04-12T22:24:59Z |
| format | Article |
| id | doaj.art-55dd4e71842b43dc9ef3852400437484 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-04-12T22:24:59Z |
| publishDate | 2021-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-55dd4e71842b43dc9ef38524004374842022-12-22T03:14:11ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542021-01-0152423924810.5937/scriptamed52-335682490-33292104239NComparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patientsNinković-Baroš Đuka0Gajanin Vesna1Zrnić Bogdan2Gajanin Živorad3Katalina Gordana4University Clinical Centre of the Republic of Srpska, Skin and Venereal Diseases Clinic, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, The Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Faculty of Medicine, The Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre of the Republic of Srpska, Skin and Venereal Diseases Clinic, Banja Luka, The Republic of Srpska, Bosnia and HerzegovinaBackground: According to the cause, chronic urticaria is most frequently divided into autoimmune and idiopathic urticaria. Aim of the paper was to determine the frequency of autoimmune urticaria using autologous serum skin testing and a comparative analysis of chronic idiopathic and chronic autoimmune urticaria by disease course, severity and most common comorbidities. Methods: Analysis covered 64 adult patients of both sexes with chronic urticaria, divided into two groups according to their positivity in autologous serum skin testing (group I with positive test and group II with negative test). General haematological and biochemical parameters, antithyroid antibodies, hepatitis serum markers, Helicobacter pylori and Borrelia burgdorferi antibodies were performed for patients in both groups. First group patients were treated by autologous blood therapy (autohaemotherapy). The analytical statistical tool SPSS (Statistical Product and Service Solutions) version 20 for descriptive statistics and statistical methods was used. The significance level used was p = 0.05. Results: The frequency of positive autologous serum test in total population of patients with chronic urticaria was 43.8 %. The average duration of urticaria was 20 months in both groups. Statistically significant difference was found in weekly scores between the studied groups (p = 0.032) in favour of chronic autoimmune urticaria with a positive autologous serum test. Subjects with chronic autoimmune urticaria had a significantly higher association with autoimmune thyroid diseases. Conclusions: Direct relation was established between the use of autologous blood therapy in patients with autoimmune chronic urticaria and improvement of the clinical picture.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2021/2490-33292104239N.pdfautologous serum skin testautoimmune chronic urticariaidiopathic chronic urticaria |
| spellingShingle | Ninković-Baroš Đuka Gajanin Vesna Zrnić Bogdan Gajanin Živorad Katalina Gordana Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients Scripta Medica autologous serum skin test autoimmune chronic urticaria idiopathic chronic urticaria |
| title | Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| title_full | Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| title_fullStr | Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| title_full_unstemmed | Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| title_short | Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| title_sort | comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients |
| topic | autologous serum skin test autoimmune chronic urticaria idiopathic chronic urticaria |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2021/2490-33292104239N.pdf |
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