Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade

Programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockade is a promising therapy for various cancer types, but most patients are still resistant. Therefore, a larger number of predictive biomarkers is necessary. In this study, we assessed whether a loss-of-function mutation of the interf...

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Bibliographic Details
Main Authors: Julie Vackova, Adrianna Piatakova, Ingrid Polakova, Michal Smahel
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
immune checkpoint therapy
cancer
pd-1/pd-l1
ifngr1
ifn-α
ifn-β
mhc class i
Online Access:https://www.mdpi.com/1422-0067/21/5/1806

Internet

https://www.mdpi.com/1422-0067/21/5/1806

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