The association between adult-type hypolactasia and symptoms of functional dyspepsia
Abstract Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Stud...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2018-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005001103&lng=en&tlng=en |
| _version_ | 1818193329540562944 |
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| author | André Castagna Wortmann Daniel Simon Luiz Edmundo Mazzoleni Guilherme Becker Sander Carlos Fernando de Magalhães Francesconi Débora Dreher Nabinger Camila Schultz Grott Tássia Flores Rech Felipe Mazzoleni Vagner Ricardo Lunge Laura Renata de Bona Tobias Cancian Milbradt Themis Reverbel da Silveira |
| author_facet | André Castagna Wortmann Daniel Simon Luiz Edmundo Mazzoleni Guilherme Becker Sander Carlos Fernando de Magalhães Francesconi Débora Dreher Nabinger Camila Schultz Grott Tássia Flores Rech Felipe Mazzoleni Vagner Ricardo Lunge Laura Renata de Bona Tobias Cancian Milbradt Themis Reverbel da Silveira |
| author_sort | André Castagna Wortmann |
| collection | DOAJ |
| description | Abstract Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia. |
| first_indexed | 2024-12-12T00:44:40Z |
| format | Article |
| id | doaj.art-55df4d05b0cc4cc080d7c089a5cbe1ac |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-12T00:44:40Z |
| publishDate | 2018-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-55df4d05b0cc4cc080d7c089a5cbe1ac2022-12-22T00:44:09ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852018-01-01010.1590/1678-4685-gmb-2017-0015S1415-47572018005001103The association between adult-type hypolactasia and symptoms of functional dyspepsiaAndré Castagna WortmannDaniel SimonLuiz Edmundo MazzoleniGuilherme Becker SanderCarlos Fernando de Magalhães FrancesconiDébora Dreher NabingerCamila Schultz GrottTássia Flores RechFelipe MazzoleniVagner Ricardo LungeLaura Renata de BonaTobias Cancian MilbradtThemis Reverbel da SilveiraAbstract Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005001103&lng=en&tlng=enbloatingdyspepsiagastrointestinal diseaseslactose intolerancesingle nucleotide polymorphism |
| spellingShingle | André Castagna Wortmann Daniel Simon Luiz Edmundo Mazzoleni Guilherme Becker Sander Carlos Fernando de Magalhães Francesconi Débora Dreher Nabinger Camila Schultz Grott Tássia Flores Rech Felipe Mazzoleni Vagner Ricardo Lunge Laura Renata de Bona Tobias Cancian Milbradt Themis Reverbel da Silveira The association between adult-type hypolactasia and symptoms of functional dyspepsia Genetics and Molecular Biology bloating dyspepsia gastrointestinal diseases lactose intolerance single nucleotide polymorphism |
| title | The association between adult-type hypolactasia and symptoms of functional dyspepsia |
| title_full | The association between adult-type hypolactasia and symptoms of functional dyspepsia |
| title_fullStr | The association between adult-type hypolactasia and symptoms of functional dyspepsia |
| title_full_unstemmed | The association between adult-type hypolactasia and symptoms of functional dyspepsia |
| title_short | The association between adult-type hypolactasia and symptoms of functional dyspepsia |
| title_sort | association between adult type hypolactasia and symptoms of functional dyspepsia |
| topic | bloating dyspepsia gastrointestinal diseases lactose intolerance single nucleotide polymorphism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005001103&lng=en&tlng=en |
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