Inflammasome activation by viral infection: mechanisms of activation and regulation
Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell. During viral infection, inflammasomes play important roles in the host an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1247377/full |
| _version_ | 1797752195745054720 |
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| author | Wen Shi Mengyun Jin Hao Chen Zongxue Wu Liuyang Yuan Si Liang Xiaohan Wang Fareed Uddin Memon Fatma Eldemery Hongbin Si Hongbin Si Hongbin Si Changbo Ou Changbo Ou Changbo Ou |
| author_facet | Wen Shi Mengyun Jin Hao Chen Zongxue Wu Liuyang Yuan Si Liang Xiaohan Wang Fareed Uddin Memon Fatma Eldemery Hongbin Si Hongbin Si Hongbin Si Changbo Ou Changbo Ou Changbo Ou |
| author_sort | Wen Shi |
| collection | DOAJ |
| description | Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell. During viral infection, inflammasomes play important roles in the host and confer defense mechanisms against the virus. Inflammasomes are polymeric protein complexes and are considered important components of the innate immune system. These immune factors recognize the signals of cell damage or pathogenic microbial infection after activation by the canonical pathway or non-canonical pathway and transmit signals to the immune system to initiate the inflammatory responses. However, some viruses inhibit the activation of the inflammasomes in order to replicate and proliferate in the host. In recent years, the role of inflammasome activation and/or inhibition during viral infection has been increasingly recognized. Therefore, in this review, we describe the biological properties of the inflammasome associated with viral infection, discuss the potential mechanisms that activate and/or inhibit NLRP1, NLRP3, and AIM2 inflammasomes by different viruses, and summarize the reciprocal regulatory effects of viral infection on the NLRP3 inflammasome in order to explore the relationship between viral infection and inflammasomes. This review will pave the way for future studies on the activation mechanisms of inflammasomes and provide novel insights for the development of antiviral therapies. |
| first_indexed | 2024-03-12T16:59:40Z |
| format | Article |
| id | doaj.art-55dfc30c52f14360a99353fc55400b96 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T16:59:40Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-55dfc30c52f14360a99353fc55400b962023-08-07T16:12:53ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-08-011410.3389/fmicb.2023.12473771247377Inflammasome activation by viral infection: mechanisms of activation and regulationWen Shi0Mengyun Jin1Hao Chen2Zongxue Wu3Liuyang Yuan4Si Liang5Xiaohan Wang6Fareed Uddin Memon7Fatma Eldemery8Hongbin Si9Hongbin Si10Hongbin Si11Changbo Ou12Changbo Ou13Changbo Ou14College of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaQYH Biotech Ltd., Beijing, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaDepartment of Hygiene and Zoonoses, Faculty of Veterinary Medicine, Mansoura University, Mansoura, EgyptCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaGuangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, ChinaGuangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaGuangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, ChinaGuangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, ChinaViral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell. During viral infection, inflammasomes play important roles in the host and confer defense mechanisms against the virus. Inflammasomes are polymeric protein complexes and are considered important components of the innate immune system. These immune factors recognize the signals of cell damage or pathogenic microbial infection after activation by the canonical pathway or non-canonical pathway and transmit signals to the immune system to initiate the inflammatory responses. However, some viruses inhibit the activation of the inflammasomes in order to replicate and proliferate in the host. In recent years, the role of inflammasome activation and/or inhibition during viral infection has been increasingly recognized. Therefore, in this review, we describe the biological properties of the inflammasome associated with viral infection, discuss the potential mechanisms that activate and/or inhibit NLRP1, NLRP3, and AIM2 inflammasomes by different viruses, and summarize the reciprocal regulatory effects of viral infection on the NLRP3 inflammasome in order to explore the relationship between viral infection and inflammasomes. This review will pave the way for future studies on the activation mechanisms of inflammasomes and provide novel insights for the development of antiviral therapies.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1247377/fullInflammasomevirus infectioninflammatory responseNLRPregulation |
| spellingShingle | Wen Shi Mengyun Jin Hao Chen Zongxue Wu Liuyang Yuan Si Liang Xiaohan Wang Fareed Uddin Memon Fatma Eldemery Hongbin Si Hongbin Si Hongbin Si Changbo Ou Changbo Ou Changbo Ou Inflammasome activation by viral infection: mechanisms of activation and regulation Frontiers in Microbiology Inflammasome virus infection inflammatory response NLRP regulation |
| title | Inflammasome activation by viral infection: mechanisms of activation and regulation |
| title_full | Inflammasome activation by viral infection: mechanisms of activation and regulation |
| title_fullStr | Inflammasome activation by viral infection: mechanisms of activation and regulation |
| title_full_unstemmed | Inflammasome activation by viral infection: mechanisms of activation and regulation |
| title_short | Inflammasome activation by viral infection: mechanisms of activation and regulation |
| title_sort | inflammasome activation by viral infection mechanisms of activation and regulation |
| topic | Inflammasome virus infection inflammatory response NLRP regulation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1247377/full |
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